Evidence map›Paper›PMID 30325932›Full record

ArticlePloS one2018

Persistently high incidence of HIV and poor service uptake in adolescent girls and young women in rural KwaZulu-Natal, South Africa prior to DREAMS.

Natsayi Chimbindi, Nondumiso Mthiyane, Isolde Birdthistle, Sian Floyd, Nuala McGrath, Deenan Pillay, Janet Seeley, Thembelihle Zuma, Jaco Dreyer, Dickman Gareta and 6 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Natsayi ChimbindiAfrica Health Research Institute, Durban, South Africa.
Nondumiso MthiyaneAfrica Health Research Institute, Durban, South Africa.
Isolde BirdthistleLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Sian FloydLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Nuala McGrathSouthampton University, Southampton, United Kingdom.
Deenan PillayAfrica Health Research Institute, Durban, South Africa.
Janet SeeleyAfrica Health Research Institute, Durban, South Africa.
Thembelihle ZumaAfrica Health Research Institute, Durban, South Africa.
Jaco DreyerAfrica Health Research Institute, Durban, South Africa.
Dickman GaretaAfrica Health Research Institute, Durban, South Africa.
Tinofa MutevedziAfrica Health Research Institute, Durban, South Africa.
Justin FentyLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Kobus HerbstAfrica Health Research Institute, Durban, South Africa.
Theresa SmitAfrica Health Research Institute, Durban, South Africa.
Kathy BaisleyAfrica Health Research Institute, Durban, South Africa.
Maryam ShahmaneshAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0001-7129-8535
Africa Health Research Institute · ZALondon School of Hygiene & Tropical Medicine · GBUniversity of Southampton · GB

Funding

Maximizing combination HIV prevention, uptake and retention by adolescent girls and young womenR01MH114560 · NIMH · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI SHAHMANESH, MARYAM · 2017 to 2023
$2.0M
Medical Research Council MR/K012126/1NIMH NIH HHS R01 MH114560Wellcome TrustWellcome Trust 082384/Z/07/Z
6 · The paper itself

Abstract

backgroundAdolescent girls and young women (AGYW) bear the brunt of the HIV epidemic in South Africa. 'DREAMS' aims to reduce HIV incidence through multi-level combination prevention. We describe HIV incidence and uptake of HIV and sexual reproductive health (SRH) by AGYW in KwaZulu-Natal (KZN), prior to DREAMS.

methodsLongitudinal and cross-sectional analysis of women (15-24 year old) in a population-based HIV incidence cohort within a demographic surveillance site in KZN. Observation time for HIV incidence was person-years at risk while resident. "Current use of contraceptives" and "having an HIV test in the past 12 months" was compared between 2011 and 2015.

resultsIn 2015, HIV prevalence was 11.0% and 34.1% and HIV incidence (2011-2015) was 4.54% (95%CI:3.89-5.30) and 7.45% (95%CI:6.51-8.51) per year in 15-19 and 20-24 year olds respectively, with no significant decline compared to 2006-2010. In 2015, 90.7% of 20-24-year-olds were unemployed, 36.4% and 51.7% of 15-19 and 20-24 year olds reported recent migration; 20.9% and 72.6% of 15-19 and 20-24 year olds had ever been pregnant. In 2015, less than 50% reported condom-use at last sex, 15.0% of 15-19 year olds and 48.9% of 20-24 year olds were currently using contraception and 32.0% and 66.7% of 15-19 and 20-24 year olds had tested for HIV in the past 12 months. There had been no improvement compared to 2011. Factors associated with AGYW testing for HIV in the past 12 months were, survey year-2011 more likely than 2015 (aOR = 0.50), number of partners (aOR = 3.25), ever been pregnant (aOR = 2.47) and knowing where to find ART (aOR = 1.54). Factors associated with contraception use were being older (aOR = 4.83); ever been pregnant (aOR = 12.62); knowing where to get ART (aOR = 1.79) and having had an HIV test in past 12 months (aOR = 1.74).

conclusionPrior to DREAMS, HIV incidence in AGYW was high. HIV and SRH service uptake did not improve and was suboptimal. Findings highlight the need for combination HIV prevention programmes for AGYW in this economically vulnerable area.

Indexed as

Sexual BehaviorAdolescentAdultContraceptionFemaleHIVHIV InfectionsHumansMalePregnancyRisk FactorsRural PopulationSexual PartnersSouth AfricaYoung Adult

Identifiers

PMID30325932
PMCPMC6191091
OpenAlexW2897190201

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.