Evidence map›Paper›PMID 30325858›Full record

ArticlePancreas

Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Chronic Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Christopher E Forsmark, Dana K Andersen, John T Farrar, Megan Golden, Aida Habtezion, Sohail Z Husain, Liang Li, Julia Mayerle, Stephen J Pandol, Aliye Uc and 2 more

Abstract readConference Proceedings
In one paragraph

Article in Pancreas. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Biomarkers of Chronic Pancreatitis: A systematic literature review.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher E Forsmark
Dana K AndersenDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
John T FarrarDepartments of Epidemiology, Neurology, and Anesthesia, University of Pennsylvania Philadelphia, PA.
Megan GoldenMission: Cure, Chicago, IL.
Aida HabtezionDepartment of Medicine, Stanford University Stanford, CA.
Sohail Z HusainDivision of Pediatric Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA.
Liang LiDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX.
Julia MayerleDepartment of Medicine II, Ludwig Maximilians University and Polyklinik, Munich, Germany.
Stephen J PandolDivision of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Aliye UcDivision of Gastroenterology, Stead Family Department of Pediatrics, University of Iowa School of Medicine, Iowa City, IA.
Zixi ZhuMission: Cure, Chicago, IL.
Dhiraj YadavDivision of Gastroenterology, University of Pittsburgh, Pittsburgh, PA.

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
Vector and Human Acinar CoreP01DK098108 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2014 to 2018
$8.1M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic CancerU01DK108300 · NIDDK · STANFORD UNIVERSITY · PI Sohail Z Husain, Walter Gwang-Up Park · 2015 to 2026
$6.3M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
U-01 CONSORTIUM FOR THE STUDY OF CHRONIC PANCREATITIS,DIABETES AND PANCREATIC CANCER CLINICAL CENTERSU01DK108320 · NIDDK · UNIVERSITY OF FLORIDA · PI CUSI, KENNETH, FORSMARK, CHRISTOPHER E · 2015 to 2024
$4.6M
NIAAA NIH HHS P50 AA011999NIDDK NIH HHS P01 DK098108NIDDK NIH HHS P30 DK054759NIDDK NIH HHS U01 DK108300NIDDK NIH HHS U01 DK108306NIDDK NIH HHS U01 DK108314NIDDK NIH HHS U01 DK108320NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP.

Indexed as

Acute DiseaseBiomedical ResearchClinical Trials as TopicDrug DevelopmentHumansNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.)PancreatitisPancreatitis, ChronicPharmaceutical PreparationsUnited StatesPharmaceutical Preparations

Identifiers

PMID30325858
PMCPMC6196743

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.