Evidence map›Paper›PMID 30325856›Full record

ArticlePancreas

Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Maisam Abu-El-Haija, Anna S Gukovskaya, Dana K Andersen, Timothy B Gardner, Peter Hegyi, Stephen J Pandol, Georgios I Papachristou, Ashok K Saluja, Vikesh K Singh, Aliye Uc and 1 more

Abstract readConference Proceedings
In one paragraph

Article in Pancreas. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. A single center randomized double blind controlled trial of pentoxifylline in acute pancreatitis: Challenges and opportunities.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020
    Trial
  3. Review
  4. Targeted therapeutics for pancreatitis.Frontiers in physiology · 2026
    Review
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  8. Observational
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Maisam Abu-El-Haija
Anna S Gukovskaya
Dana K AndersenDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Timothy B GardnerDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, Darmouth University, Hanover, NH.
Peter Hegyi
Stephen J PandolDivision of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Georgios I Papachristou
Ashok K SalujaDepartment of Surgery, Miller School of Medicine, University of Miami, Miami, FL.
Vikesh K SinghDivision of Gastroenterology, Department of Medicine, University of John's Hopkins, Baltimore, MD.
Aliye UcStead Family Department of Pediatrics, University of Iowa, Stead Family Children's Hospital, Iowa City, IA.
Bechien U WuCenter for Pancreatic Care, Department of Gastroenterology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.
Cedars-Sinai Medical Center · USDartmouth–Hitchcock Medical Center · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Iowa Stead Family Children’s Hospital · USUniversity of Miami · US

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
Vector and Human Acinar CoreP01DK098108 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2014 to 2018
$8.1M
Predicting Severity and Improving the Outcomes of Pediatric PancreatitisK23DK118190 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ABU-EL-HAIJA, MAISAM · 2018 to 2022
$947k
Cell Death and Autophagy in Chronic PancreatitisI01BX004306 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI GUKOVSKAYA, ANNA S. · 2018 to 2021
–
BLRD VA I01 BX004306NIAAA NIH HHS P50 AA011999NIDDK NIH HHS K23 DK118190NIDDK NIH HHS P01 DK098108NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities on drug development for pancreatitis. This conference was held on July 25, 2018, and structured into 3 working groups (WG): acute pancreatitis (AP) WG, recurrent AP WG, and chronic pancreatitis WG. This article reports the outcome of the work accomplished by the AP WG to provide the natural history, epidemiology, and current management of AP; inform about the role of preclinical models in therapy selection; and discuss clinical trial designs with clinical and patient-reported outcomes to test new therapies.

Indexed as

Acute DiseaseBiomedical ResearchClinical Trials as TopicDrug DevelopmentHumansNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.)PancreatitisPancreatitis, ChronicPharmaceutical PreparationsUnited StatesPharmaceutical Preparations

Identifiers

PMID30325856
PMCPMC6692135
OpenAlexW2897948228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.