ArticleAging2018
Inflammation markers are associated with frailty in elderly patients with coronary heart disease.
Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies.Aging clinical and experimental research · 2022Pooled it
- Association of inflammatory indicators with intensive care unit mortality in critically ill patients with coronary heart disease.Frontiers in immunology · 2023Trial
- The Association Between Inflammatory Scores and Frailty Severity: An Exploratory Retrospective Analysis in Non-Small-Cell Lung Cancer Surgical Patients.Medical sciences (Basel, Switzerland) · 2026Article
- Interaction between depressive symptoms and social support on frailty risk among patients with chronic heart failure.Frontiers in cardiovascular medicine · 2026Article
- The association between frailty index and all-cause mortality in US individuals with kidney stones: mediation by systemic immune-inflammation (SII) index.Urolithiasis · 2025Article
- High red blood cell distribution width associated with incident frailty in patients with cardiometabolic diseases: A longitudinal study.Scientific reports · 2025Article
- The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study.BMC neurology · 2025Article
- Inflammatory markers and clinical factors as key independent risk factors for frailty: a retrospective study.BMC geriatrics · 2025Article
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- Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD.Clinical interventions in aging · 2025Article
- Correlations between frailty index and inflammatory markers derived from blood cell count in the United States.BMC public health · 2024Article
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- Predictive value of triglyceride glucose index combined with neutrophil-to-lymphocyte ratio for major adverse cardiac events after PCI for acute ST-segment elevation myocardial infarction.Scientific reports · 2024Article
- The effect of the nutritional status and dietary inflammatory index on frailty and activities of daily living in geriatric outpatients.Irish journal of medical science · 2024Article
- Effects of aerobic exercise on myocardial injury, NF-B expression, glucolipid metabolism and inflammatory factors in rats with coronary heart disease.Clinics (Sao Paulo, Brazil) · 2024Article
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- Levels and clinical significance of the m6A methyltransferase METTL14 in patients with coronary heart disease.Frontiers in cardiovascular medicine · 2023Article
- Mediating Effect of Loneliness in the Relationship between Depressive Symptoms and Cognitive Frailty in Community-Dwelling Older Adults.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) are important indicators of adverse outcomes and have predictive value for many diseases; however, the relationships between frailty, and the NLR and RDW in patients with coronary heart disease (CHD) have not been determined. In this cross-sectional study, we investigated the association between frailty, and the NLR and RDW in elderly CHD patients ≥ 60 years of age. Frailty was defined according to frailty phenotype. Of 345 patients enrolled in the study, 22.6%, 58.3%, and 19.1% were characterized as robust, pre-frail, and frail, respectively. A significant positive correlation was observed between frailty and the NLR (r = 0.169) and RDW (r = 0.196). After adjusting for confounders, linear regression analyses showed that participants in the 4th quartile of the NLR or RDW were more likely to have a higher frailty phenotype score. Based on multivariable logistic regression, patients in the 4th quartile of the NLR and RDW, the fully-adjusted odds ratios for incident frailty were 2.894 (p = 0.011) and 2.494 (p = 0.040), respectively. Our findings indicate that frailty is associated with the NLR and RDW in elderly patients with CHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.