Evidence map›Paper›PMID 30325568›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Rapid Structure Determination of Microcrystalline Molecular Compounds Using Electron Diffraction.

Tim Gruene, Julian T C Wennmacher, Christan Zaubitzer, Julian J Holstein, Jonas Heidler, Ariane Fecteau-Lefebvre, Sacha De Carlo, Elisabeth Müller, Kenneth N Goldie, Irene Regeni and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed
44.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 279 citations in OpenAlex.

  1. Article
  2. Unnatural C6-Substituted d-Galactosides as Attenuated Substrates of Glycosyl Hydrolases.Chembiochem : a European journal of chemical biology · 2026
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  16. Structure of L-arginine and detection of trace DL-arginine by 3D ED.Acta crystallographica. Section C, Structural chemistry · 2025
    Article
  17. Article
  18. Biosourced Functional Hydroxybenzoate-Journal of the American Chemical Society · 2025
    Article
  19. Article
  20. Review

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Tim GrueneDepartment of Energy and Environment, Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.ORCID 0000-0002-8873-4978
Julian T C WennmacherDepartment of Energy and Environment, Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.
Christan ZaubitzerScientific Center for Optical and Electron Microscopy, ETH Zürich, Auguste-Piccard-Hof 1, 8093, Zürich, Switzerland.
Julian J HolsteinDepartment of Chemical and Chemical Biology, TU Dortmund University, Otto-Hahn-Straße 6, 44227, Dortmund, Germany.
Jonas HeidlerDepartment of Biology and Chemistry, Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.
Ariane Fecteau-LefebvreCenter for Cellular Imaging and NanoAnalytics, University of Basel, Mattenstrasse 26, 4058, Basel, Switzerland.
Sacha De CarloDECTRIS Ltd., Taefernweg 1, 5405, Baden-Daettwil, Switzerland.ORCID 0000-0002-9375-4498
Elisabeth MüllerElectron Microscopy Facility, Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.
Kenneth N GoldieCenter for Cellular Imaging and NanoAnalytics, University of Basel, Mattenstrasse 26, 4058, Basel, Switzerland.
Irene RegeniDepartment of Chemical and Chemical Biology, TU Dortmund University, Otto-Hahn-Straße 6, 44227, Dortmund, Germany.
Teng LiDepartment of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093, Zürich, Switzerland.
Gustavo Santiso-QuinonesCrystallise! AG, Grabenstrasse 11a, 8952, Schlieren, Switzerland.
Gunther SteinfeldCrystallise! AG, Grabenstrasse 11a, 8952, Schlieren, Switzerland.
Stephan HandschinScientific Center for Optical and Electron Microscopy, ETH Zürich, Auguste-Piccard-Hof 1, 8093, Zürich, Switzerland.
Eric van GenderenDepartment of Biology and Chemistry, Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.
Jeroen A van BokhovenDepartment of Energy and Environment, Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.
Guido H CleverDepartment of Chemical and Chemical Biology, TU Dortmund University, Otto-Hahn-Straße 6, 44227, Dortmund, Germany.
Radosav PantelicDepartment of Biology and Chemistry, Paul Scherrer Institut, Forschungsstrasse 111, 5232, Villigen PSI, Switzerland.
Paul Scherrer Institute · CHETH Zurich · CHTU Dortmund University · DECell Medica (Switzerland) · CHUniversity of Basel · CHTris Pharma (United States) · US

Funding

Swiss National Science Foundation 200021_169258
6 · The paper itself

Abstract

Chemists of all fields currently publish about 50 000 crystal structures per year, the vast majority of which are X-ray structures. We determined two molecular structures by employing electron rather than X-ray diffraction. For this purpose, an EIGER hybrid pixel detector was fitted to a transmission electron microscope, yielding an electron diffractometer. The structure of a new methylene blue derivative was determined at 0.9 Å resolution from a crystal smaller than 1×2 μm

Indexed as

chemical crystallographyelectron crystallographymethylene blue derivativesstructure determination

Identifiers

PMID30325568
PMCPMC6468266
OpenAlexW2897736099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.