Evidence map›Paper›PMID 30325510›Full record

ArticleThe Laryngoscope2019

Supporting cell survival after cochlear implant surgery.

Alvin deTorres, Rafal T Olszewski, Ivan A Lopez, Akira Ishiyama, Fred H Linthicum, Michael Hoa

Abstract readCase Reports
In one paragraph

Article in The Laryngoscope, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alvin deTorresDepartment of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC.ORCID 0000-0003-4060-4338
Rafal T Olszewskithe Auditory Development and Restoration Program.
Ivan A Lopezthe NIDCD National Temporal Bone Laboratory at University of California, Los Angeles.
Akira Ishiyamathe NIDCD National Temporal Bone Laboratory at University of California, Los Angeles.
Fred H Linthicumthe NIDCD National Temporal Bone Laboratory at University of California, Los Angeles.
Michael HoaDepartment of Otolaryngology-Head and Neck Surgery, Georgetown University Medical Center, Washington, DC.
National Physical Laboratory · GBGeorgetown University · US

Funding

Cellular and Molecular Pathways for Hearing Restoration in the Adult Inner EarZIADC000088 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI HOA, MICHAEL · 2015 to 2025
$14.0M
The Human Temporal Bone Laboratory Resource for Basic and Applied Inner Ear SciencesU24DC015910 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, AKIRA · 2017 to 2022
$4.2M
Intramural NIH HHS ZIA DC000088National Institute of Deafness and Other Communication Disorders (NIDCD) Extramural Research Fund 1U24DC015910-01National Institute of Deafness and Other Communication Disorders (NIDCD) Intramural Research Program 1ZIADC000088-02NIDCD NIH HHS U24 DC015910
6 · The paper itself

Abstract

Supporting cells (SCs) provide structure and maintain an environment that allows hair cells to receive and transmit signals in the auditory pathway. After insult to hair cells and ganglion cells, SCs respond by marking unsalvageable cells for death and maintain structural integrity. Although the histopathology after cochlear implantation has been described regarding hair cells and neural structures, surviving SCs in the implanted ear have not. We present a patient whose posthumous examination of an implanted cochlea demonstrated SC survival. This finding has implications for SC function in maintaining electrical hearing and candidacy for future hair cell regeneration therapies. Laryngoscope, 129:E36-E40, 2019.

Indexed as

Cochlear ImplantationCochlear ImplantsAged, 80 and overCell SurvivalCochleaHearing Loss, SensorineuralHumansImmunohistochemistryMaleCochlear implantendolymphatic hydropshistopathologyspiral ligamentsupporting cell

Identifiers

PMID30325510
PMCPMC6320269
OpenAlexW2896389471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.