Evidence map›Paper›PMID 30325407›Full record

ArticleAmerican journal of epidemiology2019

Social Isolation and Mortality in US Black and White Men and Women.

Kassandra I Alcaraz, Katherine S Eddens, Jennifer L Blase, W Ryan Diver, Alpa V Patel, Lauren R Teras, Victoria L Stevens, Eric J Jacobs, Susan M Gapstur

Abstract read
In one paragraph

Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
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  7. Article
  8. The (un-)Social Brain in Isolation.Physiological research · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Racial Differences in the Association Between Loneliness and Cognitive Impairment Among Older Black and White Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kassandra I AlcarazBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Katherine S EddensDepartment of Health, Behavior and Society, College of Public Health, University of Kentucky, Lexington, Kentucky.
Jennifer L BlaseSchool of Computer Science, Georgia Institute of Technology, Atlanta, Georgia.
W Ryan DiverBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Alpa V PatelBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Lauren R TerasBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Victoria L StevensBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Eric J JacobsBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Susan M GapsturBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.

Funding

Supplement for Kentucky BIRCWH Program: Training the Next Generation of Women's Health Scholars: Dr. ConnerK12DA035150 · NIDA · UNIVERSITY OF KENTUCKY · PI Thomas E Curry · 2012 to 2026
$9.0M
NIDA NIH HHS K12 DA035150
6 · The paper itself

Abstract

Social isolation is associated with higher mortality in studies comprising mostly white adults, yet associations among black adults are unclear. In this prospective cohort study, we evaluated whether associations of social isolation with all-cause, cardiovascular disease, and cancer mortality differed by race and sex. Adults enrolled in Cancer Prevention Study II in 1982/1983 were followed for mortality through 2012 (n = 580,182). Sex- and race-specific multivariable-adjusted hazard ratios and 95% confidence intervals were estimated for associations of a 5-point social isolation score with risk of death. Social isolation was associated with all-cause mortality in all subgroups (P for trend ≤ 0.005); for the most isolated versus the least isolated, the hazard ratios were 2.34 (95% confidence interval (CI): 1.58, 3.46) and 1.60 (95% CI: 1.41, 1.82) among black men and white men, respectively (P for interaction = 0.40) and 2.13 (95% CI: 1.44, 3.15) and 1.84 (95% CI: 1.68, 2.01) among black women and white women, respectively (P for interaction = 0.89). The association did not differ between black men and black women (P for interaction = 0.33) but was slightly stronger in white women than in white men (P for interaction = 0.01). Social isolation was associated with cardiovascular disease mortality in each subgroup (P for trend < 0.03) but with cancer mortality only among whites (P for trend < 0.0001). Subgroup differences in the influence of specific social isolation components were identified. Identifying and intervening with socially isolated adults could improve health outcomes.

Indexed as

Social IsolationAdultAgedBlack or African AmericanCardiovascular DiseasesFemaleHumansMaleMiddle AgedNeoplasmsProportional Hazards ModelsProspective StudiesRace FactorsRisk FactorsSex FactorsSocial Participation

Identifiers

PMID30325407
PMCPMC6321805

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.