Evidence map›Paper›PMID 30325352›Full record

ArticleScientific data2018

A radiogenomic dataset of non-small cell lung cancer.

Shaimaa Bakr, Olivier Gevaert, Sebastian Echegaray, Kelsey Ayers, Mu Zhou, Majid Shafiq, Hong Zheng, Jalen Anthony Benson, Weiruo Zhang, Ann N C Leung and 7 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Insights into pet-based radiogenomics in oncology: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2025
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shaimaa BakrDepartment of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
Olivier GevaertDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sebastian EchegarayDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kelsey AyersDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mu ZhouDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Majid ShafiqDepartment of Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205, USA.
Hong ZhengDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jalen Anthony BensonDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Weiruo ZhangDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ann N C LeungDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael KadochDepartment of Radiology, University of California Davis, Sacramento, CA 95817, USA.
Chuong D HoangThoracic and GI Oncology Branch, National Institutes of Health/National Cancer Institute, MD 20892, USA.
Joseph ShragerStanford School of Medicine, Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford, CA 94305, USA.
Andrew QuonDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Daniel L RubinDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sylvia K PlevritisDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sandy NapelDepartment of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6876-5507

Funding

microRNA regulatory networks in thoracic cancersZIABC011657 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HOANG, CHUONG · 2015 to 2025
$18.1M
Qualification and Deployment of Imaging Biomarkers of Cancer Treatment ResponseU01CA190214 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2015 to 2020
$3.1M
Tools for Linking and Mining image and Genomic Data in Non-Small Cell Lung CancerR01CA160251 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., PLEVRITIS, SYLVIA KATINA · 2011 to 2015
$2.9M
Computing, Optimizing, and Evaluating Quantitative Cancer Imaging BiomarkersU01CA187947 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., RUBIN, DANIEL L · 2015 to 2019
$2.9M
Computerized Quantitative Imaging Assessment of Tumor BurdenU01CA142555 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2010 to 2014
$2.9M
Radiogenomics Framework for Non-Invasive Personalized MedicineR01EB020527 · NIBIB · STANFORD UNIVERSITY · PI GEVAERT, OLIVIER · 2015 to 2018
$2.3M
NCI NIH HHS R01 CA160251NCI NIH HHS U01 CA142555NCI NIH HHS U01 CA187947NCI NIH HHS U01 CA190214NIBIB NIH HHS R01 EB020527
6 · The paper itself

Abstract

Medical image biomarkers of cancer promise improvements in patient care through advances in precision medicine. Compared to genomic biomarkers, image biomarkers provide the advantages of being non-invasive, and characterizing a heterogeneous tumor in its entirety, as opposed to limited tissue available via biopsy. We developed a unique radiogenomic dataset from a Non-Small Cell Lung Cancer (NSCLC) cohort of 211 subjects. The dataset comprises Computed Tomography (CT), Positron Emission Tomography (PET)/CT images, semantic annotations of the tumors as observed on the medical images using a controlled vocabulary, and segmentation maps of tumors in the CT scans. Imaging data are also paired with results of gene mutation analyses, gene expression microarrays and RNA sequencing data from samples of surgically excised tumor tissue, and clinical data, including survival outcomes. This dataset was created to facilitate the discovery of the underlying relationship between tumor molecular and medical image features, as well as the development and evaluation of prognostic medical image biomarkers.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsHumansPositron-Emission TomographySequence Analysis, RNASurvival AnalysisTomography, X-Ray Computed

Identifiers

PMID30325352
PMCPMC6190740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.