Evidence map›Paper›PMID 30325278›Full record

ArticleRadiology2019

Four-dimensional Flow MRI as a Marker for Risk Stratification of Gastroesophageal Varices in Patients with Liver Cirrhosis.

Utaroh Motosugi, Alejandro Roldán-Alzate, Peter Bannas, Adnan Said, Sean Kelly, Ryan Zea, Oliver Wieben, Scott B Reeder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. 4D Flow MRI Reflects Physiological Hemodynamics for the Diagnosis and Management of Portosystemic Shunts.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  9. Review
  10. Article
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  18. Validation of 4D flow cardiovascular magnetic resonance in TIPS stent grafts using a 3D-printed flow phantom.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Utaroh MotosugiFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).ORCID 0000-0002-6743-9793
Alejandro Roldán-AlzateFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).
Peter BannasFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).
Adnan SaidFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).
Sean KellyFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).
Ryan ZeaFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).
Oliver WiebenFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).
Scott B ReederFrom the Department of Radiology (U.M., A.R.A., P.B., O.W., S.B.R.), Department of Mechanical Engineering (A.R.A.), Division of Gastroenterology and Hepatology, Department of Medicine (A.S.), Department of Biostatistics & Medical Informatics (R.Z.), Department of Medical Physics (O.W., S.B.R.), Department of Medicine (S.B.R.), Department of Biomedical Engineering (S.B.R.), and Department of Emergency Medicine (S.B.R.), University of Wisconsin, Madison, Wis; Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan (U.M.); Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (P.B.); and Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio (S.K.).
University of Wisconsin–Madison · USUniversität Hamburg · DE

Funding

Quantitative Hemodynamics of the Liver with 4D Flow MRIR01DK096169 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., WIEBEN, OLIVER · 2012 to 2014
$1000k
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK096169
6 · The paper itself

Abstract

Purpose To assess the feasibility of four-dimensional (4D) flow MRI as a noninvasive imaging marker for stratifying the risk of variceal bleeding in patients with liver cirrhosis. Materials and Methods This study recruited participants scheduled for both liver MRI and gastroesophageal endoscopy. Risk of variceal bleeding was assessed at endoscopy by using a three-point scale: no varices, low risk, and high risk requiring treatment. Four-dimensional flow MRI was used to create angiograms for evaluating visibility of varices and to measure flow volumes in main portal vein (PV), superior mesenteric vein, splenic vein (SV), and azygos vein. Fractional flow changes in PV and SV were calculated to quantify shunting (outflow) from PV and SV into varices. Logistic analysis was used to identify the independent indicator of high-risk varices. Results There were 23 participants (mean age, 52.3 years; age range, 25-75 years), including 14 men (mean age, 51.7 years; age range, 25-75 years) and nine women (mean age, 53.2 years; age range, 31-72 years) with no varices (n = 8), low-risk varices (n = 8), and high-risk varices (n = 7) determined at endoscopy. Four-dimensional flow MRI-based angiography helped radiologists to view varices in four of 15 participants with varices. Independent indicators of high-risk varices were flow volume in the azygos vein greater than 0.1 L/min (P = .034; 100% sensitivity [seven of seven] and 62% specificity [10 of 16]) and fractional flow change in PV of less than 0 (P < .001; 100% sensitivity [seven of seven] and 94% specificity [15 of 16]). Conclusion Azygos flow greater than 0.1 L/min and portal venous flow less than the sum of splenic and superior mesenteric vein flow are useful markers to stratify the risk of gastroesophageal varices bleeding in patients with liver cirrhosis. © RSNA, 2018 Online supplemental material is available for this article.

Indexed as

Esophageal and Gastric VaricesLiver CirrhosisAdultAgedFemaleHumansHypertension, PortalImaging, Three-DimensionalLiver CirculationMagnetic Resonance ImagingMaleMiddle AgedPortal SystemProspective StudiesRisk Factors

Identifiers

PMID30325278
PMCPMC6312435
OpenAlexW2897163756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.