ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019
Analysis of polyvinyl alcohol release from commercially available daily disposable contact lenses using an in vitro eye model.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Improvement of the Stability of Functionalized PVA Nanofibers for Sensitive Compound Incorporation by Gentle Freeze-Thaw Treatment.ACS omega · 2026Article
- 3D-Printed Contact Lenses to Release Polyvinyl Alcohol as a Therapeutic Agent for the Treatment of Dry Eyes.Pharmaceutics · 2025Article
- Controlled PVA Release from Chemical-Physical Interpenetrating Networks to Treat Dry Eyes.ACS omega · 2025Article
- The Impact of Comfort Eluting Agents and Replacement Frequency on Enhancing Contact Lens Performance.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- A Rapid Screening Platform for Simultaneous Evaluation of Biodegradation and Therapeutic Release of an Ocular Hydrogel.Pharmaceutics · 2023Article
- Sustained Release of a Polymeric Wetting Agent from a Silicone-Hydrogel Contact Lens Material.ACS omega · 2022Article
- Carboxymethyl Cellulose Entrapped in a Poly(vinyl) Alcohol Network: Plant-Based Scaffolds for Cartilage Tissue Engineering.Molecules (Basel, Switzerland) · 2021Article
- Development of an Eye Model With a Physiological Blink Mechanism.Translational vision science & technology · 2019Article
- Analysis of polyvinyl alcohol release from commercially available daily disposable contact lenses using an in vitro eye model.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
Abstract
The purpose of this work was to determine the release of polyvinyl alcohol (PVA) from etafilcon A, omafilcon A, and nelfilcon A daily disposable hydrogel contact lenses using a novel in vitro model. PVA is an ocular lubricant that can be found in multiple formulations of artificial tears. Nelfilcon A innately contains PVA, so only the release of PVA from this lens was evaluated. Etafilcon A and omafilcon A lenses were incubated in a PBS solution containing PVA. The release of PVA was evaluated using a novel in vitro blink platform with Milli-Q water and PBS under various blink conditions and flow rates. Nelfilcon A lenses significantly released more PVA than other lenses at 0.5 and 1.5 h in both PBS and Milli-Q water (p < 0.001). For nelfilcon A, there was no statistical significance between the release profiles of PVA between the blink and no-blink conditions, or for the various flow rates (p > 0.05). All tested groups and lenses showed a burst release within the first 4.5 h and rapidly plateaued thereafter. The current study demonstrates that releasable PVA (whether through uptake or through being inherently available from the material) is loosely bound on hydrogel lenses, and the majority is released within 4.5 h. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1662-1668, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.