ArticleJournal of veterinary internal medicine2018
Factors associated with survival in dogs with chronic kidney disease.
Article in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Effect of trilostane treatment on proteinuria secondary to spontaneous hypercortisolism in dogs.Journal of veterinary internal medicine · 2026Article
- Survival of dogs with glomerular disease in Europe: insights from the European Veterinary Renal Pathology Service.Journal of veterinary internal medicine · 2026Article
- Muscle Mass Is a Better Predictor of Survival in Dogs With Chronic Kidney Disease Compared to Body Condition Score.Journal of animal physiology and animal nutrition · 2026Article
- Assessment of Pancreatic Lipase Activity Using a Quantitative and a Qualitative Assay in Dogs with Chronic Kidney Disease.Animals : an open access journal from MDPI · 2026Article
- Remission of severe familial proteinuria in a Bracco Italiano dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- Calciprotein particles in cats with naturally occurring chronic kidney disease.Journal of veterinary internal medicine · 2026Article
- Overall survival with beraprost in dogs with IRIS stage 2 chronic kidney disease.Frontiers in veterinary science · 2026Article
- Dogs and cats with acute-on-chronic kidney disease have worse outcomes than those with acute kidney injury following renal replacement therapy.Frontiers in veterinary science · 2026Article
- Low-protein diet for chronic kidney disease: Evidence, controversies, and practical guidelines.Journal of internal medicine · 2025Review
- Chlorambucil Monotherapy in Dogs with Protein-Losing Nephropathy of Probable Immune Origin: A Preliminary Study.Veterinary sciences · 2025Article
- Replicating the real-world evidence methods available in human health to assess burden and outcomes for dogs with chronic kidney disease, their owners, and the veterinary healthcare system in the United States of America.Frontiers in veterinary science · 2025Article
- Predictive value of physical and blood examination findings for short-term mortality in dogs with respiratory disorders.PloS one · 2025Article
- Amlodipine improves symmetric dimethylarginine in dogs with chronic kidney disease.Frontiers in veterinary science · 2025Article
- Sodium glucose transporter 2 inhibitors: Will these drugs benefit non-diabetic veterinary patients with cardiac and kidney diseases?Journal of veterinary pharmacology and therapeutics · 2025Review
- Bilateral Global Nephrocalcinosis in a Uremic Puppy.Veterinary sciences · 2024Article
- Effect of Oligo-Fucoidan, Fucoxanthin, and L-Carnitine on Chronic Kidney Disease in Dogs: A Retrospective Study.Animals : an open access journal from MDPI · 2024Article
- A comprehensive analysis of albuminuria in canine chronic kidney disease.Veterinary medicine and science · 2024Article
- Serum symmetric dimethylarginine concentrations in enalapril- or telmisartan-treated dogs with proteinuric chronic kidney disease.Frontiers in veterinary science · 2024Article
- Deep learning-based ultrasonographic classification of canine chronic kidney disease.Frontiers in veterinary science · 2024Article
- Applying Sequential Pattern Mining to Investigate the Temporal Relationships between Commonly Occurring Internal Medicine Diseases and Intervals for the Risk of Concurrent Disease in Canine Patients.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) is associated with morbidity and mortality in dogs. Plasma fibroblast growth factor-23 (FGF-23) concentration is an independent predictor of CKD progression and survival in cats and people with CKD.
objectivesTo investigate the relationship among FGF-23, parathyroid hormone (PTH), vitamin D metabolites, and other clinical variables with survival time in dogs with CKD. ANIMALS: Twenty-seven azotemic CKD dogs.
methodsDogs were recruited prospectively into the study and followed until death or study conclusion. Dogs were International Renal Interest Society (IRIS) staged into stage 2 (n = 9), stage 3 (n = 12), and stage 4 (n = 6) CKD. Survival times were calculated from the date of study inclusion. Univariable Cox regression was used to assess variables associated with survival including body condition score (BCS), muscle condition score, hematocrit, creatinine, CKD stage, serum phosphorus, urine protein:creatinine ratio (UPC), calcium phosphorus product (CaPP), PTH, 25-hydroxyvitamin D, 1,25--dihydroxyvitamin D, and FGF-23 concentrations.
resultsSignificant hazard ratios (hazard ratio; 95% confidence interval; P value) were as follows: BCS < 4/9 (1.579; 1.003-2.282; P = .05), muscle atrophy (2.334; 1.352-4.030; P = .01), increased creatinine (1.383; 1.16-1.64; .01), hyperphosphatemia (3.20; 1.357-7.548; P = .005), increased UPC (3.191; 1.310-7.773; P = .01), increased CaPP (4.092; 1.771-9.454; P = .003), and increased FGF-23 (2.609; 1.090-6.240; P = .05). Survival times for each IRIS CKD stage were significantly different (P = .01). CONCLUSIONS AND CLINICAL IMPORTANCE: Multiple variables, including FGF-23, were associated with duration of survival in CKD dogs. FGF-23 could be a prognostic marker in dogs with CKD.
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