ArticleJournal of the American Geriatrics Society2018
National Trends in Liver Transplantation in Older Adults.
Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Pulmonary function test parameters before liver transplantation predict post-transplant survival and respiratory-related death.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026Article
- Interactions Between Donor and Recipient age in Liver Transplantation: Implications for Donor and Recipient Matching.Transplantation · 2026Article
- Anti-obesity Pharmacotherapy for Transplant Recipients.Current atherosclerosis reports · 2026Review
- An In-depth overview of artificial intelligence (AI) tool utilization across diverse phases of organ transplantation.Journal of translational medicine · 2025Review
- Beyond 75: Graft Allocation and Organ Utility Implications in Liver Transplantation.Transplantation direct · 2024Article
- Increasing Healthcare System Empathy for Patients with Advanced Liver Disease: My Top 10 Lessons in Palliative Hepatology.Digestive diseases and sciences · 2024Article
- The 5Ms of Geriatrics in Gastroenterology: The Path to Creating Age-Friendly Care for Older Adults With Inflammatory Bowel Diseases and Cirrhosis.Clinical and translational gastroenterology · 2022Article
- Understanding the Impact of Pneumonia and Other Complications in Elderly Liver Transplant Recipients: An Analysis of NSQIP Transplant.Transplantation direct · 2021Article
- Multicenter Study of Age, Frailty, and Waitlist Mortality Among Liver Transplant Candidates.Annals of surgery · 2020Article
- Differential Impact of Age Among Liver Transplant Candidates With and Without Hepatocellular Carcinoma.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2020Article
- Impact of Having a Planned Additional Operation at Time of Liver Transplant on Graft and Patient Outcomes.Journal of clinical medicine · 2020Article
- Article
- PRO: Older Adults Should Be Offered Liver Transplantation.Clinical liver disease · 2019Review
- Survival benefit of accepting livers from deceased donors over 70 years old.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo explore trends in liver transplantation (LT) and outcomes for older recipients for evaluation, counseling, and appropriate referral of this vulnerable group of older adults.
designProspective national cohort study.
settingScientific Registry of Transplant Recipients (January 1, 2003-December 31, 2016).
participantsOlder (aged ≥ 65) deceased donor liver-only transplant recipients (n=8,627). MEASUREMENTS: We evaluated temporal changes in recipient, donor, and transplant characteristics and post-LT length of stay (LOS), acute rejection, graft loss, and mortality using logistic regression and Cox proportional hazards.
resultsLT in older adults almost quadrupled, from 263 in 2003 (9.5% of total LTs that year) to 1,144 in 2016 (20.7% of total LTs). Recent recipients were more likely to be female and African American and have a higher body mass index and Model for End-Stage Liver Disease score. Hepatitis C, nonalcoholic steatohepatitis, and hepatocellular carcinoma were the most common indications for LT in recent recipients. Odds of LOS longer than 2 weeks decreased 34% from 2003-06 to 2013-16 (adjusted odds ratio (aOR)=0.66, 95% confidence interval (CI)=0.57-0.76, P < .001), 1-year acute rejection decreased 30% (aOR=0.70, 95% CI=0.56-0.88, P = .002), all-cause graft loss decreased 54% (adjusted hazard ratio (aHR)=0.46, 95% CI=0.40-0.52, P < .001), and mortality decreased 57% (aHR=0.43, 95% CI=0.38-0.49, P < .001).
conclusionDespite the substantial increase in the number of older adults undergoing LT and the severity of their condition, LOS, rejection, graft loss, and mortality have significantly decreased over time. These trends can help guide appropriate LT referral and counseling in older adults with end-stage liver disease. J Am Geriatr Soc 66:2321-2326, 2018.
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