ArticleeLife2018
Maturing
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 139 citations in OpenAlex.
- The polar landscape of bacterial pathogens and predators.Current opinion in microbiology · 2026Review
- Polar growth factor PgfA regulates polar peptidoglycan synthesis as well as mycolate synthesis inJournal of bacteriology · 2026Article
- Genetic interference of distinctive Mycobacterium tuberculosis peptidoglycan modifications enhances β-lactam susceptibility and reveals expression-sensitive host immune dynamics.Scientific reports · 2026Article
- Peptide Mimetic Platform for Activity Profiling of Mycobacterial l,d-Transpeptidases.Biochemistry · 2026Article
- Article
- Activity Profiling of Mycobacterial L,D-Transpeptidases.bioRxiv : the preprint server for biology · 2026Article
- Impairment of two non-essential LytR-cpsA-psr (Lcp) cell wall ligases decelerate cell wall assembly in Mycolicibacterium smegmatis.BMC microbiology · 2026Article
- Article
- Peptidoglycan LD-Transpeptidases.Antibiotics (Basel, Switzerland) · 2025Review
- Targeting mycobacterial transpeptidases: evaluating the roles of Ldt and PBP inhibition in suppressingAntimicrobial agents and chemotherapy · 2025Article
- The multiple roles of the NlpC_P60 peptidase family in mycobacteria - an underexplored target for antimicrobial drug discovery.FEBS letters · 2025Review
- TheFrontiers in microbiology · 2025Article
- The combinatorial deletion of mycobacterial dd-carboxypeptidases is readily tolerated in Mycobacterium smegmatis.Access microbiology · 2025Article
- Single-cell imaging of the Mycobacterium tuberculosis cell cycle reveals linear and heterogenous growth.Nature microbiology · 2024Article
- Mechanisms conferring bacterial cell wall variability and adaptivity.Biochemical Society transactions · 2024Review
- MmpL3, Wag31, and PlrA are involved in coordinating polar growth with peptidoglycan metabolism and nutrient availability.Journal of bacteriology · 2024Article
- LD-transpeptidation is crucial for fitness and polar growth in Agrobacterium tumefaciens.PLoS genetics · 2024Article
- Lactic acid bacteria secreted proteins as potential Listeria monocytogenes quorum sensing inhibitors.Molecular diversity · 2024Article
- Antibacterial efficacy of mycobacteriophages against virulent Mycobacterium tuberculosis.BMC microbiology · 2024Article
- Identification of a family of peptidoglycan transpeptidases reveals thatProceedings of the National Academy of Sciences of the United States of America · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
14 authors at 4 institutions in 3 countries.
Catherine BaranowskiDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, United States.ORCID https://orcid.org/0000-0003-0407-8609
Michael A WelshDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, United States.ORCID http://orcid.org/0000-0001-8268-6285
Lok-To ShamDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, United States.
Haig A EskandarianSchool of Life Sciences, Swiss Federal Institute of Technology in Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-0610-0550
Hoong Chuin LimDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, United States.
Karen J KieserDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, United States.
Jeffrey C WagnerDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, United States.
John D McKinneySchool of Life Sciences, Swiss Federal Institute of Technology in Lausanne, Lausanne, Switzerland.
Georg E FantnerSchool of Engineering, Swiss Federal Institute of Technology in Lausanne, Lausanne, Switzerland.
Thomas R IoergerDepartment of Computer Science and Engineering, Texas A&M University, Texas, United States.
Suzanne WalkerDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, United States.
Thomas G BernhardtDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, United States.ORCID http://orcid.org/0000-0003-3566-7756
Eric J RubinDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, United States.ORCID https://orcid.org/0000-0001-5120-962X
E Hesper RegoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, United States.ORCID http://orcid.org/0000-0002-2973-8354
Harvard University · USÉcole Polytechnique Fédérale de Lausanne · CHTexas A&M University · USYale University · US
Funding
Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2014 to 2018
$25.2MThe roles of genes critical for growth under defined conditions in vitro or duriU19AI107774 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CARR, STEVEN A, FORTUNE, SARAH · 2013 to 2017
$13.2MPeptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3MMechanism and Inhibition of Enzymes that Assemble Bacterial Cell WallR01GM076710 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2007 to 2019
$5.9MMycobacterial single cell drug susceptibilityF32AI104287 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI REGO, ELIZABETH HESPER · 2014 to 2016
$148kBiochemical characterization of LMW PBPS with novel transpeptidase activityF32GM123579 · NIGMS · HARVARD MEDICAL SCHOOL · PI WELSH, MICHAEL AVERY · 2017 to 2019
$130kEuropean Research Council 307338NIAID NIH HHS F32 AI104287NIAID NIH HHS R01 AI083365NIAID NIH HHS U19 AI107774NIAID NIH HHS U19 AI109764NIGMS NIH HHS F32 GM123579NIGMS NIH HHS R01 GM076710NIH HHS F32AI104287NIH HHS F32GM123579NIH HHS R01AI083365NIH HHS R01 GM76710NIH HHS U19 AI107774NIH HHS U19AI109764Swiss National Science Foundation 205320_152675Swiss National Science Foundation 205321_134786Swiss National Science Foundation 310030_156945
Abstract
In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual crosslinks, we characterized
Indexed as
Amino AcidsAminoacyltransferasesAmoxicillinBacillusCell WallCross-Linking ReagentsEscherichia coliFluorescenceKineticsMeropenemMicrobial ViabilityModels, BiologicalMycobacterium smegmatisPenicillin-Binding ProteinsPeptidoglycanAmino AcidsAminoacyltransferasesAmoxicillinCross-Linking ReagentsMeropenemPenicillin-Binding ProteinsPeptidoglycanpeptidoglycan transpeptidaseinfectious diseasemicrobiologyMycobacterium smegmatisMycobacterium tuberculosispeptidoglycanpolar growthrod shape maintenance
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.