ArticleMolecular pain
Pain-related white matter tract abnormalities in mild traumatic brain injury patients with persistent headache.
Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- fMRI findings in MTBI patients with headaches following rTMS.Scientific reports · 2021Trial
- Diffusion tensor imaging of white matter integrity and pain-related outcomes in chronic nonspecific neck pain.Scientific reports · 2025Article
- White matter tract differences in persistent post-traumatic headache, migraine, and healthy controls: a diffusion tensor imaging study.The journal of headache and pain · 2025Article
- Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
- Phenotyping Pain in Patients With Fibrous Dysplasia/McCune-Albright Syndrome.The Journal of clinical endocrinology and metabolism · 2024Article
- Diffusion tensor imaging in the courtroom: Distinction between scientific specificity and legally admissible evidence.World journal of clinical cases · 2023Review
- Unveiling the phantom: What neuroimaging has taught us about phantom limb pain.Brain and behavior · 2022Review
- Brainstem Diffusion Tensor Tractography and Clinical Applications in Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Early Changes in the White Matter Microstructure and Connectome Underlie Cognitive Deficit and Depression Symptoms After Mild Traumatic Brain Injury.Frontiers in neurology · 2022Article
- Study design for a randomized clinical trial of cognitive-behavioral therapy for posttraumatic headache.Contemporary clinical trials communications · 2021Article
- Disrupted White Matter Functional Connectivity With the Cerebral Cortex in Migraine Patients.Frontiers in neuroscience · 2021Article
- Low brain endocannabinoids associated with persistent non-goal directed nighttime hyperactivity after traumatic brain injury in mice.Scientific reports · 2020Article
- Addressing chronic persistent headaches after MTBI as a neuropathic pain state.The journal of headache and pain · 2020Review
- The Relation between Persistent Post-Traumatic Headache and PTSD: Similarities and Possible Differences.International journal of environmental research and public health · 2020Review
- Changes in Empathy in Patients With Chronic Low Back Pain: A Structural-Functional Magnetic Resonance Imaging Study.Frontiers in human neuroscience · 2020Article
- Using Functional Near-Infrared Spectroscopy to Study the Effect of Repetitive Transcranial Magnetic Stimulation in Concussion: A Two-Patient Case Study.Frontiers in neurology · 2019Article
- Differential roles of dopamine D1 and D2 receptors in pain modulation: a review.Frontiers in neurologyReview
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe occurrence of debilitating chronic persistent (24/7) headache after mild traumatic brain injury represents a central neuropathic pain state. Previous studies suggest that this chronic headache state can be attributed to altered supraspinal modulatory functional connectivity in both resting and evoked pain states. Abnormalities in the myelin sheaths along the supraspinal superior longitudinal fasciculus and anterior thalamic radiation are frequently associated with alteration in pain modulation related to functional connectivity deficit with the prefrontal cortex. This study assessed the correlated axonal injury-related white matter tract abnormality underlying these previously observed prefrontal functional connectivity deficits by comparing the fractional anisotropy, axial diffusivity, and radial diffusivity of brain white matter in patients with mild traumatic brain injury-related headache to healthy controls.
resultDiffusion tensor imaging data from patients ( N = 12, average age ± SD = 35.0 ± 8.0 years old, 10 male) with mild traumatic brain injury-headache were compared with images acquired from healthy controls. The mild traumatic brain injury cohort demonstrated two areas of significant ( P < 0.01, F value >16, cluster size >50 voxels) white matter tract abnormalities closely related to pain affective and modulatory functions in (1) the left superior longitudinal fasciculus which connects the prefrontal cortices with the parietal cortices and (2) the right anterior thalamic radiation connecting the prefrontal cortices with the anterior cingulate cortex. In addition, a significant ( P < 0.01) decrease in axial diffusivity and increase in radial diffusivity at the superior longitudinal fasciculus cluster were noted in the mild traumatic brain injury cohort.
conclusionThe identified white matter tract abnormalities may represent a state of Wallerian degeneration which correlates with the functional connectivity deficit in pain modulation and can contribute to the development of the chronic persistent headache in the patients with mild traumatic brain injury.
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