Evidence map›Paper›PMID 30324807›Full record

ArticleEpigenomics2018

Physical activity and epigenetic biomarkers in maternal blood during pregnancy.

Sylvia E Badon, Alyson J Littman, Kwun Chuen Gary Chan, Mahlet G Tadesse, Patricia L Stapleton, Theo K Bammler, Tanya K Sorensen, Michelle A Williams, Daniel A Enquobahrie

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04563065 (Active Pregnancy, Prevention Against the Effects of COVID-19), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04563065 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Active Pregnancy, Prevention Against the Effects of COVID-19

TypeinterventionalSponsorUniversidad Politecnica de MadridRan2020 to 2023Enrolled280ConditionsPregnancy Complications, Pregnancy, High Risk, Pregnancy Induced Hypertension, Newborn MorbidityArmsExercise program, Healthy lifestyle advise
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Sylvia E BadonDepartment of Epidemiology, University of Washington, Seattle, WA 98185, USA.
Alyson J LittmanDepartment of Epidemiology, University of Washington, Seattle, WA 98185, USA.
Kwun Chuen Gary ChanDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Mahlet G TadesseDepartment of Mathematics & Statistics, Georgetown University, Washington, DC 20057, USA.
Patricia L StapletonDepartment of Occupational & Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.
Theo K BammlerDepartment of Occupational & Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.
Tanya K SorensenCenter for Perinatal Studies, Swedish Medical Center, Seattle, WA 98104, USA.
Michelle A WilliamsDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Daniel A EnquobahrieDepartment of Epidemiology, University of Washington, Seattle, WA 98185, USA.
University of Washington · USGeorgetown University · USHarvard University · USSwedish Medical Center · USUniversity of Puget Sound · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Joel Daniel Kaufman · 1995 to 2026
$42.5M
The Epidemiology of Marine Fatty Acids and PreeclampsiaR01HD032562 · NICHD · SWEDISH MEDICAL CENTER, FIRST HILL · PI WILLIAMS, MICHELLE A. · 1996 to 2006
$3.0M
University of Washington Reproductive, Perinatal and Pediatric Epidemiology T32HD052462 · NICHD · UNIVERSITY OF WASHINGTON · PI HOLT, VICTORIA L · 2006 to 2017
$2.7M
Vitamin D related genes and developmental origins of cardiometabolic riskK01HL103174 · NHLBI · UNIVERSITY OF WASHINGTON · PI ENQUOBAHRIE, DANIEL ASMAMAW · 2010 to 2014
$661k
NHLBI NIH HHS K01 HL103174NICHD NIH HHS R01 HD032562NICHD NIH HHS T32 HD052462NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

aimInvestigate associations of leisure time physical activity (LTPA) with DNA methylation and miRNAs during pregnancy. Patients & methods: LTPA, candidate DNA methylation and circulating miRNAs were measured (average 15 weeks gestation) in pregnant women (n = 92).

resultsEach additional hour of prepregnancy LTPA duration was associated with hypermethylation in C1orf212 (β = 0.137, 95% CI: 0.004-0.270) and higher circulating miR-146b-5p (β = 0.084, 95% CI: 0.017-0.151). Each additional metabolic equivalent hour of early-pregnancy LTPA energy expenditure was associated with higher circulating miR-21-3p (β = 0.431, 95% CI: 0.089-0.772) in women carrying female offspring, and lower circulating miR-146b-5p (β = -0.285, 95% CI: -0.528 to -0.043) and miR-517-5p (β = -0.406, 95% CI: -0.736 to -0.076) in women carrying male offspring.

conclusionOur findings suggest that LTPA may influence maternal epigenetic biomarkers, possibly in an offspring sex-specific manner.

Indexed as

DNA MethylationEpigenesis, GeneticExerciseAdultBiomarkersCell-Free Nucleic AcidsFemaleHumansMaternal Serum Screening TestsMicroRNAsPregnancyBiomarkersCell-Free Nucleic AcidsMicroRNAsDNA methylationmiRNAperipheral bloodphysical activitypregnancysex-specific

Identifiers

PMID30324807
PMCPMC6275564
OpenAlexW2897173747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.