Evidence map›Paper›PMID 30324723›Full record

ArticleHeadache2018

Recommendations on the Use of Anti-CGRP Monoclonal Antibodies in Children and Adolescents.

Christina L Szperka, Juliana VanderPluym, Serena L Orr, Christopher B Oakley, William Qubty, Irene Patniyot, Ana Marissa Lagman-Bartolome, Cynthia Morris, Jessica Gautreaux, M Cristina Victorio and 12 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Headache, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04628429 (Autonomic Functions in Migraine Patients as a Function of Migraine Status and CGRP Inhibition), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04628429 recruitingnot on this mapstarted 2020, after this paper: background citation

Autonomic Functions in Migraine Patients as a Function of Migraine Status and CGRP Inhibition

TypeobservationalSponsorMedical University of ViennaRan2020 to 2026Enrolled120ConditionsEpisodic Migraine, Chronic MigraineArmsErenumab, Galcanezumab, Fremanezumab
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
  5. Article
  6. Review
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  9. Article
  10. Article
  11. Review
  12. Evidence-based review and frontiers of migraine therapy.Neurogastroenterology and motility · 2025
    Review
  13. Article
  14. Article
  15. Monoclonal Antibodies Targeting CGRP to Treat Vestibular Migraine: A Rapid Systematic Review and Meta-Analysis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 18 institutions in 2 countries.

Christina L SzperkaDivision of Neurology, Children's Hospital of Philadelphia & Departments of Neurology & Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Juliana VanderPluymMayo Clinic, Scottsdale, AZ, USA.
Serena L OrrCincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Christopher B OakleyJohn's Hopkins University, Baltimore, MD, USA.
William QubtyUniversity of California, San Francisco, CA, USA.
Irene PatniyotBaylor College of Medicine, Houston, TX, USA.
Ana Marissa Lagman-BartolomeWomen's College Hospital and Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Cynthia MorrisSaint Louis University School of Medicine, St. Louis, MO, USA.
Jessica GautreauxLousiana State University Health Science Center and Children's Hospital New Orleans, New Orleans, LA, USA.
M Cristina VictorioAkron Children's Hospital, Akron, OH, USA.
Suzanne HaglerNicklaus Children's Hospital, Miami, FL, USA.
Sona NarulaDivision of Neurology, Children's Hospital of Philadelphia & Departments of Neurology & Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Meghan S CandeeUniversity of Utah, Primary Children's Hospital, Salt Lake City, UT, USA.
Catalina Cleves-BayonUPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Rashmi RaoLousiana State University Health Science Center and Children's Hospital New Orleans, New Orleans, LA, USA.
Robert H FryerColumbia University Medical Center, New York, NY, USA.
Alma R BickneseFeinberg School of Medicine at Northwestern University & Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Marcy YonkerChildren's Hospital Colorado, Aurora, CO, USA.
Andrew D HersheyCincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Scott W PowersCincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Peter J GoadsbyUniversity of California, San Francisco, CA, USA.
Amy A GelfandUniversity of California, San Francisco, CA, USA.
University of California, San Francisco · USChildren's Hospital of New Orleans · USUniversity of Cincinnati · USAkron Children's Hospital · USBaylor College of Medicine · USChildren's Hospital Colorado · USChildren's Hospital of Philadelphia · USChildren's Hospital of Pittsburgh · USCincinnati Children's Hospital Medical Center · USColumbia University Irving Medical Center · USHospital for Sick Children · CAJohns Hopkins University · USMayo Clinic in Arizona · USMiami Children's Hospital · USNorthwestern University · USPrimary Children's Hospital · USSaint Louis University · USUniversity of Pennsylvania · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Occipital Nerve Blocks for Acute Treatment of Pediatric MigraineK23NS102521 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SZPERKA, CHRISTINA LYNCH · 2018 to 2022
$940k
National Institute of Health K23NS102521NCATS NIH HHS UL1 TR001425NIH HHS K23NS102521NINDS NIH HHS K23 NS102521
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Practice Guidelines as TopicAdolescentAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBody SizeCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsChildClinical Trials as TopicCluster HeadacheContraindications, DrugDose-Response Relationship, DrugDose-Response Relationship, ImmunologicFemaleHealth Services AccessibilityAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsReceptors, Calcitonin Gene-Related Peptideadolescentcalcitonin gene-related peptidemigrainemonoclonal antibodypediatric

Identifiers

PMID30324723
PMCPMC6258331
OpenAlexW2896011253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.