ArticleEpilepsia2019
Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: A replication study.
Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Associations between epilepsy-related polygenic risk and brain morphology in childhood.Brain : a journal of neurology · 2026Article
- Endophenotype Research in Epilepsy Across Time.Brain sciences · 2025Article
- Article
- Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.CNS neuroscience & therapeutics · 2023Article
- Brain Diffusion Weighted Imaging Study of Mongolian Idiopathic Epilepsy.Journal of healthcare engineering · 2022Article
- Imaging Genetics in Epilepsy: Current Knowledge and New Perspectives.Frontiers in molecular neuroscience · 2022Review
- Motor hyperactivation during cognitive tasks: An endophenotype of juvenile myoclonic epilepsy.Epilepsia · 2020Article
- Heritability of alpha and sensorimotor network changes in temporal lobe epilepsy.Annals of clinical and translational neurology · 2020Article
- Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2020Article
- Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: A replication study.Epilepsia · 2019Article
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7 authors at 3 institutions in 1 country.
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Abstract
We investigated gray and white matter morphology in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) and first-degree asymptomatic relatives of patients with mTLE+HS. Using T1-weighted magnetic resonance imaging (MRI), we sought to replicate previously reported findings of structural surface abnormalities of the anterior temporal lobe in asymptomatic relatives of patients with mTLE+HS in an independent cohort. We performed whole-brain MRI in 19 patients with mTLE+HS, 14 first-degree asymptomatic relatives of mTLE+HS patients, and 32 healthy control participants. Structural alterations in patients and relatives compared to controls were assessed using automated hippocampal volumetry and cortical surface-based morphometry. We replicated previously reported cortical surface area contractions in the ipsilateral anterior temporal lobe in both patients and relatives compared to healthy controls, with asymptomatic relatives showing similar but less extensive changes than patients. These findings suggest morphologic abnormality in asymptomatic relatives of mTLE+HS patients, suggesting an inherited brain structure endophenotype.
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