Evidence map›Paper›PMID 30324602›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

Mechanisms and Measurements of Scale Invariance of Morphogen Gradients.

Yan Huang, David Umulis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yan HuangAgricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA.
David UmulisAgricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA. dumulis@purdue.edu.

Funding

Systems Analysis of BMP Regulation in Developing Zebrafish EmbryosR01HD073156 · NICHD · PURDUE UNIVERSITY · PI UMULIS, DAVID MICHAEL · 2013 to 2017
$1.5M
NICHD NIH HHS R01 HD073156
6 · The paper itself

Abstract

Morphogen gradients provide positional information to underlying cells that translate the information into differential gene expression and eventually different cell fates. Scale invariance is the property where the gradients of the morphogen adjust proportionately to the size of the domain. Scale invariance of morphogen gradients or patterns of differentiation is a common phenomenon observed between individuals within the same species and between homologous tissues or structures in different species. To determine whether or not a pattern is scale invariant, others and we have developed definitions and measurements of gradient scaling. These include point-wise and global scaling errors as well as global scaling power. Furthermore, there are a number of mathematical conditions for scale invariance of advection-diffusion-reaction models that inform mechanisms of scaling. Herein we provide a deeper perspective on modeling and measurement of scale invariance of morphogen gradients.

Indexed as

AlgorithmsEmbryonic DevelopmentModels, TheoreticalMorphogenesisAnimalsBiological TransportDiffusionIntercellular Signaling Peptides and ProteinsSignal TransductionIntercellular Signaling Peptides and ProteinsMathematical modelMorphogenesisMorphogen gradientReaction–diffusionScale invariance

Identifiers

PMID30324602
PMCPMC6763312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.