ArticlePediatric nephrology (Berlin, Germany)2019
A clinical predictive model of renal injury in children with congenital solitary functioning kidney.
Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 40 citations in OpenAlex.
- Clinical course of unilateral multicystic dysplastic kidney and contralateral kidney in Korean children: a single-center, retrospective study.Childhood kidney diseases · 2026Article
- Pelvi-Ureteric Junction Obstruction in a Solitary Functioning Kidney in Children: An Unfavourable Combination.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Kidney injury risk in congenital solitary functioning kidney: the role of nephron mass assessed by serum uromodulin and the rs4293393 T > C polymorphism.BMC research notes · 2025Article
- Congenital solitary functioning kidney: evaluations to do which, when, and how.Childhood kidney diseases · 2024Review
- Early diagnosis of solitary functioning kidney: comparing the prognosis of kidney agenesis and multicystic dysplastic kidney.Pediatric nephrology (Berlin, Germany) · 2024Article
- Solitary Functioning Kidneys Attenuate Renal Hemodynamics Responses to Angiotensin II in Male But Not in Female Rats.International journal of preventive medicine · 2024Article
- Congenital anomalies of the kidney and urinary tract: defining risk factors of disease progression and determinants of outcomes.Pediatric nephrology (Berlin, Germany) · 2023Review
- Predicting outcomes in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Comparison of axial and coronal axis MRI kidney volume measurement in pediatric congenital solitary kidney.Pediatric nephrology (Berlin, Germany) · 2023Article
- Management of the congenital solitary kidney: consensus recommendations of the Italian Society of Pediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2022Review
- Risk stratification for children with a solitary functioning kidney.Pediatric nephrology (Berlin, Germany) · 2021Article
- Outcomes of solitary functioning kidneys-renal agenesis is different than multicystic dysplastic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Retrospective evaluation of children with unilateral renal agenesis.Pediatric nephrology (Berlin, Germany) · 2021Article
- Is the prognosis of congenital single functioning kidney benign? A population-based study.Pediatric nephrology (Berlin, Germany) · 2021Article
- Clinical Management of Children with a Congenital Solitary Functioning Kidney: Overview and Recommendations.European urology open science · 2021Review
- Should we need more sensitive early diagnostic markers in children with congenital solitary functioning kidneys?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Predicting outcomes and improving care in children with congenital kidney anomalies.Pediatric nephrology (Berlin, Germany) · 2020Article
- A clinical predictive model of renal injury in children with isolated antenatal hydronephrosis.Clinical kidney journal · 2020Article
- Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney.Frontiers in physiology · 2020Review
- Editorial: Developmental Disorders of the Kidney and Urinary Tract: Recent Insights From Clinical and Molecular Studies.Frontiers in pediatrics · 2020Article
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10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundSolitary functioning kidney (SFK) is an important condition in the spectrum of congenital anomalies of the kidney and urinary tract. The aim of this study was to describe the risk factors for renal injury in a cohort of patients with congenital SFK.
methodsIn this retrospective cohort study, 162 patients with SFK were systematically followed up (median, 8.5 years). The primary endpoint was time until the occurrence of a composite event of renal injury, which includes proteinuria, hypertension, and chronic kidney disease (CKD). A predictive model was developed using Cox proportional hazards model and evaluated by c statistics.
resultsAmong 162 children with SFK included in the analysis, 132 (81.5%) presented multicystic dysplastic kidney, 20 (12.3%) renal hypodysplasia, and 10 (6.2%) unilateral renal agenesis. Of 162 patients included in the analysis, 10 (6.2%) presented persistent proteinuria, 11 (6.8%) had hypertension, 9 (5.6%) developed CKD stage ≥ 3, and 18 (11%) developed the composite outcome. After adjustment by the Cox model, three variables remained as independent predictors of the composite event: creatinine (HR, 3.93; P < 0.001), recurrent urinary tract infection (UTI) (HR, 5.05; P = 0.002), and contralateral renal length at admission (HR, 0.974; P = 0.002). The probability of the composite event at 10 years of age was estimated as 3%, 11%, and 56% for patients assigned to the low-risk, medium-risk, and high-risk groups, respectively (P < 0.001).
conclusionOur findings have shown an overall low risk of renal injury for most of infants with congenital SFK. Nevertheless, our prediction model enabled the identification of a subgroup of patients with an increased risk of renal injury over time.
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