Evidence map›Paper›PMID 30324310›Full record

ArticleInternational orthopaedics2019

Bone marrow concentrate and expanded mesenchymal stromal cell surnatants as cell-free approaches for the treatment of osteochondral defects in a preclinical animal model.

Francesca Veronesi, Giovanna Desando, Milena Fini, Annapaola Parrilli, Roberta Lolli, Melania Maglio, Lucia Martini, Gianluca Giavaresi, Isabella Bartolotti, Brunella Grigolo and 1 more

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06040957 (Bone Marrow vs Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06040957 narecruitingnot on this mapstarted 2024, after this paper: background citation

Bone Marrow vs Adipose Tissue as a Cell Source for Infiltrative Treatment of Knee Osteoarthritis: Randomized Clinical Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2024 to 2027Enrolled204ConditionsKnee OsteoarthritisArmsBone marrow aspirate concentrate injection, intra-articular injection of Minimally manipulated adipose tissue
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. The history of Italian Orthopaedics.International orthopaedics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesca VeronesiLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy.
Giovanna DesandoLaboratory RAMSES, IRCCS Rizzoli Orthopedic Institute, Bologna, Italy.
Milena FiniLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy.
Annapaola ParrilliLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy.
Roberta LolliLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy.
Melania MaglioLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy. melania.maglio@ior.it.
Lucia MartiniLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy.
Gianluca GiavaresiLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy.
Isabella BartolottiLaboratory RAMSES, IRCCS Rizzoli Orthopedic Institute, Bologna, Italy.
Brunella GrigoloLaboratory RAMSES, IRCCS Rizzoli Orthopedic Institute, Bologna, Italy.
Maria SartoriLaboratory of Preclinical and Surgical Studies, Rizzoli-RIT, IRCCS Rizzoli Orthopedic Institute, Via Di Barbiano 1/10, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the regenerative potential of surnatants (SNs) from bone marrow concentrate (SN-BMC) and expanded mesenchymal stromal cells (SN-MSCs) loaded onto a collagen scaffold (SC) in comparison with cell-based treatments (BMC and MSCs) in an osteochondral (OC) defect model in rabbits.

methodsOC defects (3 × 5 mm) were created in the rabbit femoral condyles and treated with SC alone or combined with SN-BMC, SN-MSCs, BMC, and MSCs. In control groups, the defects were left untreated. At three and six months, the quality of regenerated tissue was evaluated with macroscopic, histologic, microtomographic, and immunohistochemical assessments. The production of several immunoenzymatic markers was measured in the synovial fluid.

resultsAll proposed treatments improved OC regeneration in comparison with untreated and SC-treated defects. Both BMC and MSCs showed a similar healing potential than their respective SNs, with the best performance exerted by BMC as demonstrated with macroscopic and histological scores and type I and II collagen results.

conclusionsSNs loaded onto SC exerted a positive effect on OC defect regeneration, underlying the biological significance of the trophic factors, thus potentially opening new opportunities for the use of cell-free-based therapies. BMC was confirmed to be the most beneficial treatment.

Indexed as

Bone Marrow TransplantationMesenchymal Stem Cell TransplantationAnimalsBone MarrowBone Marrow CellsCollagenIntra-Articular FracturesKnee JointMesenchymal Stem CellsModels, AnimalRabbitsWound HealingCollagenBone marrow concentrateCell-free approachIn vivo modelMesenchymal stromal cellsOsteochondral defect

Identifiers

PMID30324310

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.