ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2018
Physicochemical characterization of ferric pyrophosphate citrate.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Revealing the nuclearity of iron citrate complexes at biologically relevant conditions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Complex Evaluation of Nanocomposite-Based Hydroxyapatite for Biomedical Applications.Biomimetics (Basel, Switzerland) · 2023Article
- Biocomposite Coatings Doped with Magnesium and Zinc Ions in Chitosan Matrix for Antimicrobial Applications.Materials (Basel, Switzerland) · 2023Article
- Studies of the Tarragon Essential Oil Effects on the Characteristics of Doped Hydroxyapatite/Chitosan Biocomposites.Polymers · 2023Article
- Achieving Selectivity for Phosphate over Pyrophosphate in Ethanol with Iron(III)-Based Fluorescent Probes.JACS Au · 2022Article
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Authors and funding
3 authors.
Funding
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Abstract
Iron deficiency is a significant health problem across the world. While many patients benefit from oral iron supplements, some, including those on hemodialysis require intravenous iron therapy to maintain adequate iron levels. Until recently, all iron compounds suitable for parenteral administration were colloidal iron-carbohydrate conjugates that require uptake and processing by macrophages. These compounds are associated with variable risk of anaphylaxis, oxidative stress, and inflammation, depending on their physicochemical characteristics. Ferric pyrophosphate citrate (FPC) is a novel iron compound that was approved for parenteral administration by US Food and Drug Administration in 2015. Here we report the physicochemical characteristics of FPC. FPC is a noncolloidal, highly water soluble, complex iron salt that does not contain a carbohydrate moiety. X-ray absorption spectroscopy data indicate that FPC consists of iron (III) complexed with one pyrophosphate and two citrate molecules in the solid state. This structure is preserved in solution and stable for several months, rendering it suitable for pharmaceutical applications in solid or solution state.
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