Dynamics of Fluorescent Imaging for Rapid Tear Thinning.

L Zhong, R J Braun, C G Begley, P E King-Smith

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Article in Bulletin of mathematical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

L ZhongDepartment of Mathematical Sciences, University of Delaware, Newark, DE, 19716, USA. lanzhong@udel.edu.ORCID http://orcid.org/0000-0002-3826-3928

R J BraunDepartment of Mathematical Sciences, University of Delaware, Newark, DE, 19716, USA.

C G BegleySchool of Optometry, Indiana University, Bloomington, IN, 47405, USA.

P E King-SmithCollege of Optometry, The Ohio State University, Columbus, OH, 43218, USA.

Funding

Interferometric Studies of the Fluid Dynamics of the Tear FilmR01EY017951 · NEI · OHIO STATE UNIVERSITY · PI KING-SMITH, PETER E · 2009 to 2012

$1.2M

Tear Instability as a Unifying Mechanism for Dry Eye SymptomsR01EY021794 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI BEGLEY, CAROLYN G · 2011 to 2015

$1.2M

NEI NIH HHS R01 EY017951NEI NIH HHS R01EY017951NEI NIH HHS R01 EY021794NIH HHS 1R01EY021794

6 · The paper itself

Abstract

A previous mathematical model has successfully simulated the rapid tear thinning caused by glob (thicker lipid) in the lipid layer. It captured a fast spreading of polar lipid and a corresponding strong tangential flow in the aqueous layer. With the simulated strong tangential flow, we now extend the model by adding equations for conservation of solutes, for osmolarity and fluorescein, in order to study their dynamics. We then compare our computed results for the resulting intensity distribution with fluorescence experiments on the tear film. We conclude that in rapid thinning, the fluorescent intensity can linearly approximate the tear film thickness well, when the initial fluorescein concentration is small. Thus, a dilute fluorescein is recommended for visualizing the rapid tear thinning during fluorescent imaging.

Indexed as

Computer SimulationDry Eye SyndromesFluoresceinFluorescent DyesHumansLipid MetabolismMathematical ConceptsModels, BiologicalOptical ImagingOsmolar ConcentrationSurface-Active AgentsSurface TensionTearsFluoresceinFluorescent DyesSurface-Active AgentsDry eyeFluorescent imagingMarangoni effectTear film

Identifiers

PMID30324271

DOI10.1007/s11538-018-0517-0

PMCPMC6781631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.