Evidence map›Paper›PMID 30324137›Full record

ArticleScience advances2018

Cryo-EM structure of

David Oyen, Jonathan L Torres, Christopher A Cottrell, C Richter King, Ian A Wilson, Andrew B Ward

Open access · greenAbstract read
In one paragraph

Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 65 citations in OpenAlex.

  1. Trial
  2. Protective near-germline antibodies to malaria elicited by RTS,S/AS01bioRxiv : the preprint server for biology · 2026
    Article
  3. Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. iScience · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The Plasmodium circumsporozoite protein.Trends in parasitology · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David OyenDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jonathan L TorresDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-0137-8497
Christopher A CottrellDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-3364-3083
C Richter KingPATH's Malaria Vaccine Initiative, PATH's Center for Vaccine Innovation and Access, Washington, DC 20001, USA.
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-6469-2419
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-9778-1776
Scripps Research Institute · US

Funding

Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BAROUCH, DAN H. · 2012 to 2018
$131.5M
6 · The paper itself

Abstract

The circumsporozoite protein (CSP) on the surface of

Indexed as

Amino Acid SequenceAnimalsAntibodies, MonoclonalAntibodies, ProtozoanAntigens, ProtozoanCryoelectron MicroscopyImmunoglobulin Fab FragmentsMalariaMalaria VaccinesMiceMutationPlasmodium falciparumProtein ConformationProtozoan ProteinsSequence HomologySporozoitesAntibodies, MonoclonalAntibodies, ProtozoanAntigens, Protozoancircumsporozoite protein, ProtozoanImmunoglobulin Fab FragmentsMalaria VaccinesProtozoan Proteins

Identifiers

PMID30324137
PMCPMC6179375
OpenAlexW2895834092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.