ReviewFrontiers in cardiovascular medicine2018
Cardiovascular Effects and Benefits of Exercise.
Review in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 395 papers, 17 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Performance and Safety of DTXO App, an Innovative Digital Therapy, in Improving Weight Loss and Weight-Loss Maintenance of Patients With Obesity by Increasing Their Adherence to Dietary, Exercise Regimens and Psycho-Behavioral Program
Effect of Low-intensity Aerobic Regular Activity on Heart Rate Variability in Type 1 Diabetes
Who cites it
395 citing papers in PubMed, 17 syntheses or guidelines pooled it, 802 citations in OpenAlex.
- Can too much exercise kill you? A systematic review of the risk of a cardiovascular event or death from long term strenuous exercise.European journal of epidemiology · 2026Pooled it
- Service Design Strategies to Enhance Exercise Adherence in Extended Reality Interventions for Older Adults: Systematic Review.JMIR aging · 2026Pooled it
- Polygenic scores and physical fitness prediction: a systematic review.Human genetics · 2026Pooled it
- Feasibility of high intensity exercise training in people with dementia and Mild Cognitive Impairment: a systematic review.BMC geriatrics · 2026Pooled it
- Mapping the effects of exercise on cognition and physical function: a scoping review of rodent studies.Frontiers in physiology · 2026Pooled it
- Effects of swimming on cognitive and health outcomes in older adults and insights into participation facilitators and barriers: a systematic review.Frontiers in medicine · 2026Pooled it
- The Use of Physical Activity in Coping with Test Anxiety Among Students: A Systematic Review.International journal of environmental research and public health · 2025Pooled it
- Personalized Interactive Music Systems for Physical Activity and Exercise: Exploratory Systematic Review and Meta-Analysis.JMIR human factors · 2025Pooled it
- Physical activity for prevention of cardiovascular disease: consensus statement of Korean Society of Cardio-cerebrovascular Disease Prevention.The Korean journal of internal medicine · 2025Guideline
- Physical training of wheelchair users with neuromuscular disorders: A systematic review.Journal of neuromuscular diseases · 2025Pooled it
- Exploring the 'fit for work' principle: The association between occupational physical activity, cardio-respiratory fitness, and mortality - a meta-analysis of male worker data.Scandinavian journal of work, environment & health · 2025Pooled it
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- The effects of high-intensity interval training on cognitive performance: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- The effects of acute exercise on stress reactivity assessed via a multidimensional approach: a systematic review.Journal of behavioral medicine · 2024Pooled it
- Atrial fibrillation catheter ablation in endurance athletes: systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Pooled it
- Effect and Mechanism of a New Method of Low-Intensity Resistance Training Combined with Blood Flow Restriction on Sports Biomechanics of Young People.Journal of sports science & medicine · 2025Trial
- Intradialytic Exercise: Effects on Arterial Stiffness and Gait Speed in Patients Undergoing Hemodialysis.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL.International journal of molecular sciences · 2025Trial
335 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is widely accepted that regular physical activity is beneficial for cardiovascular health. Frequent exercise is robustly associated with a decrease in cardiovascular mortality as well as the risk of developing cardiovascular disease. Physically active individuals have lower blood pressure, higher insulin sensitivity, and a more favorable plasma lipoprotein profile. Animal models of exercise show that repeated physical activity suppresses atherogenesis and increases the availability of vasodilatory mediators such as nitric oxide. Exercise has also been found to have beneficial effects on the heart. Acutely, exercise increases cardiac output and blood pressure, but individuals adapted to exercise show lower resting heart rate and cardiac hypertrophy. Both cardiac and vascular changes have been linked to a variety of changes in tissue metabolism and signaling, although our understanding of the contribution of the underlying mechanisms remains incomplete. Even though moderate levels of exercise have been found to be consistently associated with a reduction in cardiovascular disease risk, there is evidence to suggest that continuously high levels of exercise (e.g., marathon running) could have detrimental effects on cardiovascular health. Nevertheless, a specific dose response relationship between the extent and duration of exercise and the reduction in cardiovascular disease risk and mortality remains unclear. Further studies are needed to identify the mechanisms that impart cardiovascular benefits of exercise in order to develop more effective exercise regimens, test the interaction of exercise with diet, and develop pharmacological interventions for those unwilling or unable to exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.