Evidence map›Paper›PMID 30324088›Full record

ArticlePsoriasis (Auckland, N.Z.)2018

The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA.

Jessica A Walsh, Heather Jones, Lotus Mallbris, Kristina Callis Duffin, Gerald G Krueger, Daniel O Clegg, Annette Szumski

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Psoriasis (Auckland, N.Z.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00245960 phase4completednot on this map

A randomized, open-label, two-period study to evaluate the safety and efficacy of etanercept on skin and joint disease in psoriasis subjects with psoriatic arthritis

TypeinterventionalSponsorWyeth is now a wholly owned subsidiary of PfizerRan2005 to 2008Enrolled752ConditionsPsoriatic ArthritisArmsetanercept, Placebo
NCT00663052 phase4completednot on this map

A Randomized, Double-Blind Trial Assessing the Efficacy and Safety of Etanercept 50 mg Twice Weekly and Etanercept 50 mg Once Weekly for the Treatment of Moderate to Severe Psoriasis

TypeinterventionalSponsorPfizerRan2008 to 2010Enrolled273ConditionsPlaque Psoriasis, PsoriasisArmsEtanercept
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Measurement of Body Surface Area for Psoriasis Using U-net Models.Computational and mathematical methods in medicine · 2022
    Article
  11. Article
  12. Measuring Outcomes in Psoriatic Arthritis.Arthritis care & research · 2020
    Review
  13. Article
  14. Personalized medicine-concepts, technologies, and applications in inflammatory skin diseases.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jessica A WalshDivision of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA, jessica.walsh@hsc.utah.edu.
Heather JonesInflammation and Immunology,Global Medical Affairs, Pfizer, Collegeville, PA, USA.
Lotus MallbrisInflammation and Immunology,Global Medical Affairs, Pfizer, Collegeville, PA, USA.
Kristina Callis DuffinDepartment of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Gerald G KruegerDepartment of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Daniel O CleggDivision of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA, jessica.walsh@hsc.utah.edu.
Annette SzumskiPfizer Business Unit (PBU) Syneos Health, Princeton, NJ, United States.
University of Utah · USPfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe product of Physician Global Assessment and Body Surface Area (PGA × BSA) is a new outcome measure for psoriasis severity and response to therapy. The objective of this study was to evaluate PGA × BSA as an alternative to Psoriasis Area and Severity Index (PASI) for psoriasis assessments.

methodsThe relationship between PASI and PGA × BSA was assessed in a post hoc analysis of pooled data from the PRISTINE (NCT00663052) and PRESTA (NCT00245960) trials in patients with moderate-to-severe psoriasis who received etanercept 50 mg/week. Data were analyzed using Spearman and intra-class correlation coefficients, effect sizes, scatterplots, Bland-Altman plots, and Kappa statistics.

resultsSpearman correlations at baseline, week 12, and week 24 were strong for PGA × BSA versus PASI (

conclusionPGA × BSA has advantages over PASI for measuring moderate-to-severe psoriasis; it is intuitive, sensitive, and easy to use.

Indexed as

agreementcorrelationetanerceptPASIPGA × BSApsoriasisresponsiveness

Identifiers

PMID30324088
PMCPMC6181091
OpenAlexW2895081633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.