Evidence map›Paper›PMID 30324084›Full record

ArticleNanotheranostics2018

A Scalable Method for Squalenoylation and Assembly of Multifunctional

Samantha T Tucci, Jai W Seo, Hamilton Kakwere, Azadeh Kheirolomoom, Elizabeth S Ingham, Lisa M Mahakian, Sarah Tam, Spencer Tumbale, Mo Baikoghli, R Holland Cheng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotheranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. DNA Nanostructures and DNA-Functionalized Nanoparticles for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Samantha T TucciDepartment of Biomedical Engineering, University of California Davis, Davis, California, 95616, USA.
Jai W SeoDepartment of Radiology, Stanford University, Palo Alto, CA 94304, USA.
Hamilton KakwereDepartment of Radiology, Stanford University, Palo Alto, CA 94304, USA.
Azadeh KheirolomoomDepartment of Radiology, Stanford University, Palo Alto, CA 94304, USA.
Elizabeth S InghamDepartment of Biomedical Engineering, University of California Davis, Davis, California, 95616, USA.
Lisa M MahakianDepartment of Biomedical Engineering, University of California Davis, Davis, California, 95616, USA.
Sarah TamDepartment of Biomedical Engineering, University of California Davis, Davis, California, 95616, USA.
Spencer TumbaleDepartment of Radiology, Stanford University, Palo Alto, CA 94304, USA.
Mo BaikoghliDepartment of Molecular and Cellular Biology, University of California Davis, Davis, California, 95616, USA.
R Holland ChengDepartment of Molecular and Cellular Biology, University of California Davis, Davis, California, 95616, USA.
Katherine W FerraraDepartment of Radiology, Stanford University, Palo Alto, CA 94304, USA.
Stanford University · USPalo Alto University · US

Funding

Image-guided ultrasound therapy and drug delivery in pancreatic cancerR01CA210553 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W · 2016 to 2020
$3.2M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
NCI NIH HHS R01 CA210553NIGMS NIH HHS T32 GM099608
6 · The paper itself

Abstract

Squalenoylation of gemcitabine, a front-line therapy for pancreatic cancer, allows for improved cellular-level and system-wide drug delivery. The established methods to conjugate squalene to gemcitabine and to form nanoparticles (NPs) with the squalenoylated gemcitabine (SqGem) conjugate are cumbersome, time-consuming and can be difficult to reliably replicate. Further, the creation of multi-functional SqGem-based NP theranostics would facilitate characterization of

Indexed as

64CugemcitabineNanoparticlespancreatic cancerradiolabelingsqualene

Identifiers

PMID30324084
PMCPMC6170330
OpenAlexW2891480709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.