Evidence map›Paper›PMID 30323969›Full record

ArticleAmerican journal of cancer research2018

MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39.

Jian Jiang, Binbin Ma, Xiaojie Li, Wenlong Jin, Chuanchun Han, Ling Wang, Hong Wang

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jian JiangDepartment of Spine Surgery, First Affiliated Hospital, Institute of Cancer Stem Cell of Dalian Medical University Dalian 116011, China.
Binbin MaDepartment of Neurosurgery, Second Affiliated Hospital of Dalian Medical University Dalian 116027, China.
Xiaojie LiDepartment of Spine Surgery, First Affiliated Hospital, Institute of Cancer Stem Cell of Dalian Medical University Dalian 116011, China.
Wenlong JinDepartment of Spine Surgery, First Affiliated Hospital, Institute of Cancer Stem Cell of Dalian Medical University Dalian 116011, China.
Chuanchun HanDepartment of Spine Surgery, First Affiliated Hospital, Institute of Cancer Stem Cell of Dalian Medical University Dalian 116011, China.
Ling WangDepartment of Spine Surgery, First Affiliated Hospital, Institute of Cancer Stem Cell of Dalian Medical University Dalian 116011, China.
Hong WangDepartment of Spine Surgery, First Affiliated Hospital, Institute of Cancer Stem Cell of Dalian Medical University Dalian 116011, China.
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small regulatory non-coding RNAs that have been reported to play an important role in a variety of cellular functions. Recent studies indicated that some miRNAs are involved in regulating endoplasmic reticulum (ER) stress adaptation. However, the miRNAs were still unknown in osteosarcoma. In this study, we demonstrated that miR-1281 induced by ER stress promoted cell apoptosis and decreased ER stress adaptation of osteosarcoma

Indexed as

apoptosisER stressmiR-1281osteosarcomap53

Identifiers

PMID30323969
PMCPMC6176178
OpenAlexW2990802898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.