Evidence map›Paper›PMID 30323945›Full record

ArticleNPJ biofilms and microbiomes2018

Mucins trigger dispersal of

Julia Y Co, Gerardo Cárcamo-Oyarce, Nicole Billings, Kelsey M Wheeler, Scott C Grindy, Niels Holten-Andersen, Katharina Ribbeck

Open access · goldAbstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 92 citations in OpenAlex.

  1. Biofilm dispersion byJournal of bacteriology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. UnderstandingMicroorganisms · 2026
    Review
  8. Article
  9. Virulence · 2025
    Article
  10. Article
  11. Article
  12. iScience · 2025
    Article
  13. Article
  14. Engineered Tissue Models to Decode Host-Microbiota Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Mussel-inspired cross-linking mechanisms enhance gelation and adhesion of multifunctional mucin-derived hydrogels.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Exploring aggregation genes in aJournal of bacteriology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Coacervate Dense Phase Displaces Surface-EstablishedJournal of the American Chemical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Julia Y Co *1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Gerardo Cárcamo-Oyarce *3Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA USA.
Nicole Billings1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Kelsey M Wheeler1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Scott C Grindy4Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Niels Holten-Andersen4Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Katharina Ribbeck1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.
Massachusetts Institute of Technology · US

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Mucin Glycans in the Regulation of Microbial VirulenceR01EB017755 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RIBBECK, KATHARINA · 2013 to 2022
$3.6M
NIBIB NIH HHS R01 EB017755NIEHS NIH HHS P30 ES002109NIEHS NIH HHS T32 ES007020NIGMS NIH HHS T32 GM008334
6 · The paper itself

Abstract

Mucus is a biological gel that lines all wet epithelia in the body, including the mouth, lungs, and digestive tract, and has evolved to protect the body from pathogenic infection. However, microbial pathogenesis is often studied in mucus-free environments that lack the geometric constraints and microbial interactions in physiological three-dimensional mucus gels. We developed fluid-flow and static test systems based on purified mucin polymers, the major gel-forming constituents of the mucus barrier, to understand how the mucus barrier influences bacterial virulence, particularly the integrity of

Identifiers

PMID30323945
PMCPMC6180003
OpenAlexW2894860300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.