ArticleAmerican journal of translational research2018
Autologous fibroblasts, peripheral blood mononuclear cells, and fibrin glue accelerate healing of refractory cutaneous ulcers in diabetic mice.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Fibroblast-Based Cell Therapy: Molecular Background, Current Therapies and Future Perspectives.Cells · 2026Review
- Autologous transplantation of multilayered fibroblast sheets prevents postoperative pancreatic fistula by regulating fibrosis and angiogenesis.American journal of translational research · 2021Article
- Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function.Burns & trauma · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsWe have developed a method to transplant sheets of autologous fibroblasts and peripheral blood mononuclear cells, which are highly angiogenic and regenerative, as treatment against refractory cutaneous ulcers in mice and rabbits. The cell sheets are also sealed with fibrin to further enhance effectiveness.
methodsSecretion of growth factors from cells incubated with or without fibrin in vitro was assessed by enzyme-linked immunosorbent assays, while angiogenesis and fibroblast migration were assessed by tube formation and scratch assays. Healing of cutaneous ulcers following transplantation of cells was evaluated in mice with diabetes mellitus.
resultsSecretion of vascular endothelial growth factor, hepatocyte growth factor, and transforming growth factor was much higher from cell sheets supplemented with fibrin than from cell sheets only. Accordingly, supernatants from the former enhanced angiogenesis and fibroblast migration in vitro. Cutaneous ulcers treated with fibrin-glued cell sheets also healed more quickly than untreated ulcers or ulcers treated with cell sheets only.
conclusionFibrin-sealed cells accelerate wound healing and microvascularization by supplying growth factors, and thus are promising as treatment against refractory cutaneous ulcers.
Indexed as
Identifiers
30323878PMC6176242W2997415255What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.