Evidence map›Paper›PMID 30323817›Full record

ArticleFrontiers in immunology2018

Antiphospholipid Antibodies to Domain I of Beta-2-Glycoprotein I Show Different Subclass Predominance in Comparison to Antibodies to Whole Beta-2-glycoprotein I.

Thomas McDonnell, Bahar Artim-Esen, Chris Wincup, Vera M Ripoll, David Isenberg, Ian P Giles, Anisur Rahman, Charis Pericleous

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The Pathophysiology of The Antiphospholipid Syndrome: A Perspective From The Blood Coagulation System.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Thomas McDonnellDivision of Medicine, Rayne Institute, University College London, London, United Kingdom.
Bahar Artim-EsenDivision of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Chris WincupDivision of Medicine, Rayne Institute, University College London, London, United Kingdom.
Vera M RipollDivision of Medicine, Rayne Institute, University College London, London, United Kingdom.
David IsenbergDivision of Medicine, Rayne Institute, University College London, London, United Kingdom.
Ian P GilesDivision of Medicine, Rayne Institute, University College London, London, United Kingdom.
Anisur RahmanDivision of Medicine, Rayne Institute, University College London, London, United Kingdom.
Charis PericleousImperial College Vascular Sciences National Heart & Lung Institute, Imperial Centre for Translational and Experimental Medicine (ICTEM), London, United Kingdom.
University College London · GBIstanbul University · TR

Funding

Medical Research Council MR/P017371/1Versus Arthritis 19423Versus Arthritis 21223
6 · The paper itself

Abstract

Antiphospholipid antibodies (aPL), the serological hallmark of antiphospholipid syndrome (APS), are a heterogeneous group of autoantibodies raised against circulating blood proteins. Of these proteins, the phospholipid-binding b2-glycoprotein I (β2GPI) is considered to be the main autoantigen in APS. Indeed, IgG antibodies targeting b2GPI (ab2GPI) directly cause both thrombosis and pregnancy morbidity in several mouse models. While antibodies raised against all five domains of b2GPI have been reported, a subgroup of IgG ab2GPI raised against the first domain (DI) of b2GPI (aDI), strongly correlate with thrombotic APS, and drive thrombosis and pregnancy loss

Indexed as

AdultAnalysis of VarianceAntibodies, AntiphospholipidAntiphospholipid Syndromebeta 2-Glycoprotein IEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GMaleMiddle AgedProtein DomainsAntibodies, Antiphospholipidbeta 2-Glycoprotein IImmunoglobulin Gantiphosholipid antibodiesAntiphospholid syndromeBeta 2 glycoproteindomain IIgG 3

Identifiers

PMID30323817
PMCPMC6173128
OpenAlexW2894220218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.