Evidence map›Paper›PMID 30323816›Full record

ReviewFrontiers in immunology2018

Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells.

Huensuk Kim, Christoph Schaniel

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Microfabricated Organ-Specific Models of Tumor Microenvironments.Annual review of biomedical engineering · 2025
    Review
  4. Review
  5. Merits and challenges of iPSC-derived organoids for clinical applications.Frontiers in cell and developmental biology · 2023
    Review
  6. Review
  7. Review
  8. Generation and manipulation of human iPSC-derived platelets.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Huensuk KimBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Christoph SchanielBlack Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Icahn School of Medicine at Mount Sinai · US

Funding

System analysis of p53 mutant associated cancer development with LFS patient- specific iPSCsK00CA212489 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KIM, HUENSUK · 2018 to 2019
$168k
System analysis of p53 mutant associated cancer development with LFS patient- specific iPSCsF99CA212489 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KIM, HUENSUK · 2016 to 2017
$87k
NCI NIH HHS F99 CA212489NCI NIH HHS K00 CA212489
6 · The paper itself

Abstract

The advent of induced pluripotent stem cells (iPSCs) together with recent advances in genome editing, microphysiological systems, tissue engineering and xenograft models present new opportunities for the investigation of hematological diseases and cancer in a patient-specific context. Here we review the progress in the field and discuss the advantages, limitations, and challenges of iPSC-based malignancy modeling. We will also discuss the use of iPSCs and its derivatives as cellular sources for drug target identification, drug development and evaluation of pharmacological responses.

Indexed as

AnimalsCellular ReprogrammingDisease Models, AnimalDrug DevelopmentGene EditingHematologic DiseasesHeterograftsHumansInduced Pluripotent Stem CellsNeoplasmsTissue Engineeringblood disorderscancerhematopoietic malignanciesinduced pluripotent stem cellsmodel systems

Identifiers

PMID30323816
PMCPMC6172418
OpenAlexW2891238565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.