Evidence map›Paper›PMID 30323806›Full record

ReviewFrontiers in immunology2018

A Unique Population: Adipose-Resident Regulatory T Cells.

Qin Zeng, Xiaoxiao Sun, Liuling Xiao, Zhiguo Xie, Maria Bettini, Tuo Deng

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qin ZengDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiaoxiao SunDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Liuling XiaoCenter for Bioenergetics, Weill Cornell Medical College, Houston Methodist Research Institute, Houston, TX, United States.
Zhiguo XieDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Maria BettiniSection of Diabetes and Endocrinology, Department of Pediatrics, Baylor College of Medicine, McNair Medical Institute, Texas Children's Hospital, Houston, TX, United States.
Tuo DengDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.

Funding

TCR PARAMETERS OF TREG FUNCTION IN AUTOIMMUNITYR01AI125301 · NIAID · UNIVERSITY OF UTAH · PI BETTINI, MARIA · 2017 to 2021
$1.9M
T cell co-stimulation in obesity-induced adipose inflammationR01DK110184 · NIDDK · METHODIST HOSPITAL RESEARCH INSTITUTE · PI DENG, TUO · 2017 to 2018
$805k
NIAID NIH HHS R01 AI125301NIDDK NIH HHS R01 DK110184
6 · The paper itself

Abstract

Regulatory T (Treg) cell is well known for its anti-inflammatory function in a variety of tissues in health and disease. Accordingly, Treg cells that reside in adipose tissue exhibit specific phenotypes. Their numbers are regulated by age, gender and environmental factors, such as diet and cold stimulation. Adipose-resident Treg cells have been suggested to be critical regulators of immune and metabolic microenvironment in adipose tissue, as well as involved in pathogenesis of obesity-related metabolic disorders. This review surveys existing information on adipose-resident Treg cells. We first describe the origin, phenotype and function of adipose-resident Treg cells. We then describe the major regulators of adipose-resident Treg cells, and discuss how the adipose-resident Treg cells are regulated in lean and obese conditions, especially in humans. Finally, we highlight their therapeutic potential in obesity-related disorders.

Indexed as

Adipose TissueAnimalsHistocompatibility Antigens Class IIHumansInterleukin-1 Receptor-Like 1 ProteinInterleukin-33MaleMiceModels, AnimalObesityPhenotypePPAR gammaT-Lymphocytes, RegulatoryTranscriptomeHistocompatibility Antigens Class IIInterleukin-1 Receptor-Like 1 ProteinInterleukin-33PPAR gammaadipose tissueinflammationmetabolic diseaseobesityregulatory T cell

Identifiers

PMID30323806
PMCPMC6172295

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.