ArticleFrontiers in aging neuroscience2018
Comparative Epidemiological Investigation of Alzheimer's Disease and Colorectal Cancer: The Possible Role of Gastrointestinal Conditions in the Pathogenesis of AD.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Neuropsychiatric Disorders and Constipation: Unraveling Causal Links Through Genetic Analysis.Brain and behavior · 2026Article
- Exploring the relationship between Alzheimer's disease and colorectal/breast cancers using SEER database, Mendelian randomization, and transcriptomic data.Discover oncology · 2026Article
- Studying the Role of Myenteric Amyloidosis in Gastrointestinal Dysmotility and Enteric Neural Dysfunction Using APP/PS1 Mice-Is It an Adequate Animal Model?Neurogastroenterology and motility · 2025Article
- Mendelian randomization and transcriptomic analysis reveal a positive cause-and-effect relationship between Alzheimer's disease and colorectal cancer.Translational oncology · 2025Article
- Constipation symptoms are associated with worse cognitive outcomes in older adults without dementia.Frontiers in nutrition · 2025Article
- Bowel Health, Laxative Use, and Cognitive Function in Older Puerto Rican Adults.Journal of aging research · 2025Article
- Slow gut transit increases the risk of Alzheimer's disease: An integrated study of the bi-national cohort in South Korea and Japan and Alzheimer's disease model mice.Journal of advanced research · 2024Article
- Exploring cognitive trajectories and their association with physical performance: evidence from the China Health and Retirement Longitudinal Study.Epidemiology and health · 2023Article
- Impact of constipation on progression of Alzheimer's disease: A retrospective study.CNS neuroscience & therapeutics · 2022Article
- 5xFAD mice do not have myenteric amyloidosis, dysregulation of neuromuscular transmission or gastrointestinal dysmotility.Neurogastroenterology and motility · 2022Article
- Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice.Communications biology · 2022Article
- Editorial: Probiotics and constipation.Frontiers in nutrition · 2022Article
- MicroRNA-Target Interaction Regulatory Network in Alzheimer's Disease.Journal of personalized medicine · 2021Article
- Spermine protects aluminium chloride and iron-induced neurotoxicity in rat model of Alzheimer's disease via attenuation of tau phosphorylation, Amyloid-β (1-42) and NF-κB pathway.Inflammopharmacology · 2021Article
- Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study.Frontiers in neuroscience · 2021Article
- Constipation and Its Associated Factors among Patients with Dementia.International journal of environmental research and public health · 2020Article
- Cause of death among patients with colorectal cancer: a population-based study in the United States.Aging · 2020Article
- Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease.Current neuropharmacology · 2020Review
- The analysis of miRNA expression profiling datasets reveals inverse microRNA patterns in glioblastoma and Alzheimer's disease.Oncology reports · 2019Article
- The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review.Frontiers in aging neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder that affects approximately 35 million people worldwide, and diet has been reported to influence the prevalence/incidence of AD. Colorectal cancer is among the most common cancers in Western populations, and the correlation between constipation and the occurrence of colorectal cancer has been identified in a number of studies, which show that a Westernized diet is a mutual risk factor. Constipation is a growing health problem, particularly in middle-aged and older adults. As the most common gastrointestinal disorder in adults, constipation affects 2-20% of the world population, and it is associated with several diseases, such as diabetes, Parkinson's disease, and others. Comparing the epidemiological data on colorectal cancer and AD, we find that colorectal cancer and AD have similar epidemiologic feature, which is both disease correlate with high prevalence of constipation. Therefore, we hypothesized that constipation may influence Alzheimer's disease in a similar way that it contributes to colorectal cancer. This review aimed to systemically elucidate the evidence that constipation contributes to Alzheimer's disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.