Evidence map›Paper›PMID 30323699›Full record

ArticleJournal of blood medicine2018

HIV infection has a profound effect on hematological factors but not on electrolyte profile of Malawian adults presenting with uncomplicated malaria and severe malaria.

Alinane U Munyenyembe, Kamunkhwala Gausi, Tonney S Nyirenda, Jasmin Hiestand, Jane Mallewa, Wilson L Mandala

Abstract read
In one paragraph

Article in Journal of blood medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Hyponatremia in Infectious Diseases-A Literature Review.International journal of environmental research and public health · 2020
    Review
  5. The Effect of Frequent Exposure toInfection and drug resistance · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alinane U MunyenyembeMalawi-Liverpool Wellcome Trust, Malaria Immunology Department, Blantyre, Malawi, wmandala2002@gmail.com, amunyenyembe@mlw.mw.
Kamunkhwala GausiMalawi-Liverpool Wellcome Trust, Malaria Immunology Department, Blantyre, Malawi, wmandala2002@gmail.com, amunyenyembe@mlw.mw.
Tonney S NyirendaPathology Department, College of Medicine, Blantyre, Malawi.
Jasmin HiestandMedicine Department, College of Medicine, Blantyre, Malawi.
Jane MallewaMedicine Department, College of Medicine, Blantyre, Malawi.
Wilson L MandalaMalawi-Liverpool Wellcome Trust, Malaria Immunology Department, Blantyre, Malawi, wmandala2002@gmail.com, amunyenyembe@mlw.mw.

Funding

Wellcome Trust
6 · The paper itself

Abstract

aimAlthough malaria and HIV infections independently affect the electrolyte and hematologic profiles, little is known of how these profiles are affected in individuals coinfected with malaria and HIV. We therefore conducted this study to investigate the electrolyte and hematologic profiles of Malawian adults presenting with either uncomplicated malaria (UM), severe malaria (SM), and those presenting with HIV and UM or HIV and SM.

methodsStudy participants were recruited at Queen Elizabeth Central Hospital, and malaria infection was confirmed by rapid diagnostic test and malaria slides, and full blood count, HIV, and wet chemistries were analyzed.

resultsSodium, potassium, calcium, and chloride levels of all 4 study groups were similar to those of healthy controls. Both HIV-infected groups (UM and SM) had lower red blood cell counts and lower hemoglobin concentration than the reference range. Platelet counts were lower in both HIV-uninfected SM cases (64×10

conclusionHIV infection did not affect the electrolyte profile of Malawian adults presenting with UM or SM but had an effect on red blood cells, Hb concentration, neutrophils, and platelet counts.

Indexed as

electrolyteshematologic valuesHIV infectionHIV-malaria co-infectionMalawian AdultsPlasmodium falciparum malaria

Identifiers

PMID30323699
PMCPMC6178338

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.