ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2018
Urinary TGF-β1 was not independently associated with renal function in diabetes mellitus.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Associations of Transforming Growth Factor-β (TGF-β) with Chronic Kidney Disease Progression in Patients Attending a Tertiary Hospital in Johannesburg, South Africa.Biomedicines · 2026Article
- Urinary transforming growth factor beta-1 levels correlate with the effect of renorrhaphy on functional outcomes post-laparoscopic partial nephrectomy: A pilot-study.Arab journal of urology · 2025Article
- Study of the Urinary TGF-β1 Profile in Diabetic Nephropathy: A Single-Center Experience From India.Cureus · 2023Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundSeveral clinical studies have shown increased level of urinary TGF-β1 in diabetic nephropathy patients and its correlation with urine albumin-to-creatinine ratio (UACR), but other studies showed different results. Because of this contradiction, this study aims to analyze the correlation between urinary TGF-β1 concentration and UACR, and also estimated glomerular filtration rate (eGFR) in type 2 diabetes mellitus (DM) patients by controlling some confounding factors.
methodsThis was a cross-sectional study, and the samples were obtained using consecutive sampling technique. The study was performed on 99 subjects (62 DM normoalbuminuria patients, 27 DM albuminuria patients, and 10 non-DM patients as controls) at Pasar Minggu Community Health Center. Urinary TGF-β1 concentration was measured by ELISA, and UACR was measured using immunoturbidimetry and an enzymatic colorimetric method. The eGFR value was calculated based on serum creatinine using Chronic Kidney Disease Epidemiology Collaboration equation. The results were then subjected to be analyzed statistically.
resultsThere was an increase of urinary TGF-β1 in albuminuria (326.49±48.98) as compared to normoalbuminuria (290.54±30.71) and non-DM subjects (229.83±31.90), but the values did not differ statistically (
conclusionThere is an increase of urinary TGF-β1 concentrations in albuminuria patients clinically, but not statistically. The concentration of TGF-β1 was not correlated with UACR and eGFR, but correlated with SBP. Since TGF-β1 could be interfered by many factors, including hypertension and its medication, urinary TGF-β1 might not be independently associated with renal function in diabetes.
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