Evidence map›Paper›PMID 30323624›Full record

ArticleOncoTargets and therapy2018

miR-431-5p alters the epithelial-to-mesenchymal transition markers by targeting

Qinglei Kong, Jianhua Han, Hong Deng, Feilong Wu, Shaozhong Guo, Zhiqiang Ye

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  6. [Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
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  7. The Theory ofGenes · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qinglei KongDepartment of Emergency, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China, yezhiqiang_zssy@126.com.
Jianhua HanDepartment of Emergency, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China, yezhiqiang_zssy@126.com.
Hong DengDepartment of Infectious Disease and Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China.
Feilong WuDepartment of Emergency, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China, yezhiqiang_zssy@126.com.
Shaozhong GuoDepartment of Infectious Disease and Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China.
Zhiqiang YeDepartment of Emergency, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China, yezhiqiang_zssy@126.com.
Sun Yat-sen University · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMicroRNA (miR)-431 plays an essential role in various human cancer types, particularly in the process of invasion. However, the function and mechanism of miR-431-5p in the invasion of hepatocellular carcinoma (HCC) remain undefined.

methodsThe expression levels of miR-431-5p and its potential target protein

resultsMiR-431-5p was downregulated in HCC cell lines and tissues and associated with vascular invasion and tumor encapsulation. Furthermore, miR-431-5p was able to influence the epithelialto-mesenchymal transition (EMT) process in HCCLM3 and HUH7 cells. Mechanistically, it was discovered that miR-431-5p repressed invasion by targeting

conclusionThe current study has demonstrated that the miR-431-5p/

Indexed as

epithelial-to-mesenchymal transitionhepatocellular carcinomamicroRNA-431PBOV1UROC28

Identifiers

PMID30323624
PMCPMC6177384
OpenAlexW2895724812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.