Evidence map›Paper›PMID 30323598›Full record

ArticleInternational journal of nanomedicine2018

MnO nanoparticles with potential application in magnetic resonance imaging and drug delivery for myocardial infarction.

Yuanyuan Zheng, Hong Zhang, Yuping Hu, Lu Bai, Jingyi Xue

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Mn-Based MRI Contrast Agents: An Overview.Molecules (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Nanotechnology for cardiovascular diseases.Innovation (Cambridge (Mass.)) · 2022
    Review
  13. Review
  14. Review
  15. Review
  16. Nano-Medicine in the Cardiovascular System.Frontiers in pharmacology · 2021
    Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanyuan ZhengDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China, zhengyy@ccmu.edu.cn.
Hong ZhangDepartment of Chemistry and Biology, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Yuping HuDepartment of Chemistry and Biology, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People's Republic of China.
Lu BaiDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China, zhengyy@ccmu.edu.cn.
Jingyi XueDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China, zhengyy@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial infarction (MI) is a leading cause of death worldwide. Therefore, nanoparticles that applied for specific diagnosis of the infarcted area and/or local myocardial delivery of therapeutic agents, are highly desired. MATERIALS AND

methodsHerein, we developed the MnO-based nanoparticles, with magnetic resonance (MR) and near-infrared fluorescence imaging modalities as an MR imaging contrast agent and potential drug vehicle for the detection and treatment of MI. The chemophysical characteristics, targeting ability toward infarcted myocardium, biodistribution, and biocompatibility of the MnO-based nanoparticles were studied.

resultsIt was found that the MnO-based dual-modal nanoparticles possess high

conclusionIn summary, the use of these MnO nanoparticles as a T

Indexed as

Drug Delivery SystemsAnimalsContrast MediaFluorescenceMagnetic Resonance ImagingMaleManganese CompoundsMice, Inbred C57BLMyocardial InfarctionMyocardiumNanoparticlesOxidesParticle SizeRats, Sprague-DawleyTissue DistributionX-Ray DiffractionContrast MediaManganese Compoundsmanganese oxideOxidesCy5.5 conjugated MnO nanoparticlesDual-modal nanoprobeMyocardial ischemiaNear-infrared fluorescence imaging

Identifiers

PMID30323598
PMCPMC6181115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.