ArticlePatient preference and adherence2018
Adherence to chronic medication in older populations: application of a common protocol among three European cohorts.
Article in Patient preference and adherence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 74 citations in OpenAlex.
- The European Drug-Drug Interaction (EuroDDI) Study Protocol: A Cross-Country Comparison of Drug-Drug Interaction Prevalence in the Older Community-Dwelling Population.Pharmacoepidemiology and drug safety · 2025Article
- Therapeutic Adherence and Potentially Inappropriate Prescribing in Older Adults with Polypharmacy in Primary Health Care.Patient preference and adherence · 2025Article
- Cohort Profile: The CArdiovascular Risk factors for hEalth Services research (CARhES) cohort study.International journal of epidemiology · 2024Article
- A real-world analysis of pharmacotherapy adherence and the factors influencing it in Serbia: a nationwide, population-based, cross-sectional study.Frontiers in public health · 2024Article
- Italian Translation and Validation of the Original ABC Taxonomy for Medication Adherence.Healthcare (Basel, Switzerland) · 2023Article
- Factors Associated with Adherence to Treatment in Patients with HIV and Diabetes Mellitus.Journal of personalized medicine · 2023Article
- Study of Adherence Level and the Relationship Between Treatment Adherence, and Superstitious Thinking Related to Health Issues Among Chronic Disease Patients in Southern Jordan: Cross-Sectional Study.Patient preference and adherence · 2023Article
- The Role of Pharmaceutical Compounding in Promoting Medication Adherence.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Trends in the Prevalence of Chronic Medication Use Among Children in Israel Between 2010 and 2019: Protocol for a Retrospective Cohort Study.JMIR research protocols · 2022Article
- Agarwood-The Fragrant Molecules of a Wounded Tree.Molecules (Basel, Switzerland) · 2022Review
- 'You need to be healthy to be sick': exploring older people's experiences with medication packaging at home.Age and ageing · 2022Article
- Uncontrolled blood pressure and contributing factors among patients with hypertension at outpatient care of Bedele General Hospital, Southwest Ethiopia: A cross-sectional study.SAGE open medicine · 2022Article
- Patterns of statin adherence in primary cardiovascular disease prevention during the pandemic.Frontiers in pharmacology · 2022Article
- Persistence as a Robust Indicator of Medication Adherence-Related Quality and Performance.International journal of environmental research and public health · 2021Article
- Drug-utilisation profiles and COVID-19.Scientific reports · 2021Article
- Effect of patient and treatment factors on persistence with antihypertensive treatment: A population-based study.PloS one · 2021Observational
- Article
- New Male Users of Lipid-Lowering Drugs for Primary Prevention of Cardiovascular Disease: The Impact of Treatment Persistence on Morbimortality. A Longitudinal Study.International journal of environmental research and public health · 2020Article
- The Need to Develop Standard Measures of Patient Adherence for Big Data: Viewpoint.Journal of medical Internet research · 2020Article
- Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate and compare medication adherence to chronic therapies in older populations across different regions in Europe.
methodsThis explorative study applied a harmonized method of data extraction and analysis from pharmacy claims databases of three European countries to compare medication adherence at a cross-country level. Data were obtained for the period between January 1, 2010, and December 31, 2011. Patients (aged ≥65 years) who newly initiated to oral antidiabetics, antihyperlipidemics, or antiosteoporotics were identified and followed for over a 12-month period. Main outcome measures were medication adherence (medication possession ratio, [MPR]; implementation) and persistence on index treatment. All country-specific data sets were prepared by employing a common data input model. Outcome measures were calculated for each country and pooled using random effect models.
resultsIn total, 39,186 new users were analyzed. In pooled data from the three countries, suboptimal implementation (MPR <80%) was 52.45% (95% CI: 33.43-70.79) for antihy-perlipidemics, 61.35% (95% CI: 52.83-69.22) for antiosteoporotics, and 30.33% (95% CI: 25.53-35.60) for oral antidiabetics. Similarly, rates of non-persistence (discontinuation) were 55.63% (95% CI: 35.24-74.29) for antihyperlipidemics, 60.24% (95% CI: 45.35-73.46) for antiosteoporotics, and 46.80% (95% CI: 36.40-57.4) for oral antidiabetics.
conclusionMedication adherence was suboptimal with >50% of older people non-adherent to antihyperlipidemics and antiosteoporotics in the three European cohorts. However, the degree of variability in adherence rates among the three countries was high. A harmonized method of data extraction and analysis across health-related database in Europe is useful to compare medication-taking behavior at a cross-country level.
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