ArticleNature immunology2018
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.
0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 208 citations in OpenAlex.
- Molecular Pathogenesis of Cerebral Amyloid Angiopathy in Alzheimer's Disease: The Role of the Central Fibrinolytic Cascade at the Neurovascular Unit.Molecular neurobiology · 2026Review
- Plasmin-mediated fibrinolysis is required for hematopoietic recovery after 5-FU-induced myeloablation.Blood advances · 2026Article
- Article
- CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Fibrinogen as a Driver of Oxidative Stress and Apoptosis in the Fetal Brain After Maternal Influenza.Research square · 2026Article
- Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Role of aging‑related cytokines in neurodegenerative disease (Review).International journal of molecular medicine · 2026Review
- Three cryo-EM structures of complement C3d-bound αScience advances · 2026Article
- Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer's disease-related hyperexcitability and brain network dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Endothelial TRIM47 regulates blood-brain barrier integrity and cognition via the KEAP1/NRF2 signalling pathway in mice.Communications biology · 2026Article
- Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow.Fluids and barriers of the CNS · 2026Article
- Neuroimmune phenotypes in brain aneurysms and neurodegenerative diseases.Frontiers in neuroscience · 2026Article
- Article
- Fibrinogen in extracellular matrix remodeling: functional switching, source heterogeneity, and biomaterial translation.Frontiers in cell and developmental biology · 2026Review
- Development of a humanized anti-fibrin monoclonal antibody for the treatment of neuroinflammatory and retinal diseases.Journal of neuroinflammation · 2025Article
- Plasma Fibronectin Drives Macrophage Elongation via Integrin β3-Tie2 Axis in Blood Clots.Cancers · 2025Article
- Fibrinogen triggers perivascular fibroblast activation in a mouse model of cortical ischemic stroke.iScience · 2025Article
- Targeting hypercoagulability in ischemic stroke modulates fibrin-driven microglial polarization via JAK-STAT pathway.Journal of neuroinflammation · 2025Article
- A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain.bioRxiv : the preprint server for biology · 2025Article
- Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease.EJNMMI radiopharmacy and chemistry · 2025Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
35 authors at 7 institutions in 3 countries.
Jae Kyu RyuGladstone Institutes, San Francisco, CA, USA.
Victoria A RafalskiGladstone Institutes, San Francisco, CA, USA.
Anke Meyer-FrankeGladstone Institutes, San Francisco, CA, USA.
Ryan A AdamsDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Suresh B PodaLundbeck Research USA, Paramus, NJ, USA.
Pamela E Rios CoronadoGladstone Institutes, San Francisco, CA, USA.
Lars Østergaard PedersenH. Lundbeck A/S, Copenhagen, Denmark.
Veena MenonLundbeck Research USA, Paramus, NJ, USA.
Kim M BaetenGladstone Institutes, San Francisco, CA, USA.
Shoana L SikorskiDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Catherine BedardGladstone Institutes, San Francisco, CA, USA.
Kristina HanspersGladstone Institutes, San Francisco, CA, USA.
Sophia BardehleGladstone Institutes, San Francisco, CA, USA.
Andrew S MendiolaGladstone Institutes, San Francisco, CA, USA.
Dimitrios DavalosGladstone Institutes, San Francisco, CA, USA.
Michael R MachadoGladstone Institutes, San Francisco, CA, USA.
Justin P ChanGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2164-4724
Ioanna PlastiraGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2403-9973
Mark A PetersenGladstone Institutes, San Francisco, CA, USA.
Samuel J PfaffSmall Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Kenny K AngSmall Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Kenneth K HallenbeckSmall Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Catriona SymeGladstone Institutes, San Francisco, CA, USA.
Hiroyuki HakozakiNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Mark H EllismanNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, USA.
Raymond A SwansonNeurology Service, San Francisco Veteran Affairs Medical Center, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3664-5359
Scott S ZamvilDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Michelle R ArkinSmall Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Stevin H ZornLundbeck Research USA, Paramus, NJ, USA.
Alexander R PicoGladstone Institutes, San Francisco, CA, USA.
Lennart MuckeGladstone Institutes, San Francisco, CA, USA.
Stephen B FreedmanGladstone Institutes, San Francisco, CA, USA.
Jeffrey B StavenhagenH. Lundbeck A/S, Copenhagen, Denmark.
Robert B NelsonLundbeck Research USA, Paramus, NJ, USA.
Katerina AkassoglouGladstone Institutes, San Francisco, CA, USA. kakassoglou@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0002-2632-1465
Gladstone Institutes · USUniversity of California, San Francisco · USLundbeck (United States) · USUniversity of California San Diego · USLundbeck (Denmark) · DKCleveland Clinic · USSan Francisco VA Medical Center · US
Funding
Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7MNon-coding/epigenetic regulationP01HD084387 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Nadav Ahituv · 2016 to 2026
$14.2MNeurovascular Interactions: Mechanisms, imaging, therapeutic potentialR35NS097976 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA · 2016 to 2023
$11.1MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MPHARMACEUTICAL SCIENCES AND PHARMACOGENOMICST32GM007175 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, KROETZ, DEANNA L · 1985 to 2021
$7.1MMechanisms of Fibrin Action in Multiple SclerosisR01NS052189 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKASSOGLOU, KATERINA · 2005 to 2016
$5.1MEXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1MChild Health Career Development Program at UCSFK12HD072222 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 2013 to 2017
$2.0MRegulatory Control of Glutamate - Induced Superoxide Production [Admin Supplement]R01NS081149 · NINDS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SWANSON, RAYMOND A · 2012 to 2016
$1.7MDisease relevance of CD20 expression on T cells in multiple sclerosis patientsR01NS092835 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAUSER, STEPHEN L · 2015 to 2018
$1.7MIdentification & functional characterization of SIM1 obesity-associated variantsR01DK090382 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, VAISSE, CHRISTIAN · 2012 to 2015
$1.3MMechanisms of Fibrin Action in Neuronal FunctionsR21NS082976 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI AKASSOGLOU, KATERINA · 2014 to 2015
$525kNCI NIH HHS P30 CA082103NCRR NIH HHS C06 RR018928NIAID NIH HHS T32 AI007334NICHD NIH HHS K12 HD072222NICHD NIH HHS P01 HD084387NIDDK NIH HHS R01 DK090382NIGMS NIH HHS T32 GM007175NINDS NIH HHS F32 NS096920NINDS NIH HHS R01 NS052189NINDS NIH HHS R01 NS081149NINDS NIH HHS R01 NS092835NINDS NIH HHS R21 NS082976NINDS NIH HHS R21 NS108159NINDS NIH HHS R35 NS097976
Abstract
Activation of innate immunity and deposition of blood-derived fibrin in the central nervous system (CNS) occur in autoimmune and neurodegenerative diseases, including multiple sclerosis (MS) and Alzheimer's disease (AD). However, the mechanisms that link disruption of the blood-brain barrier (BBB) to neurodegeneration are poorly understood, and exploration of fibrin as a therapeutic target has been limited by its beneficial clotting functions. Here we report the generation of monoclonal antibody 5B8, targeted against the cryptic fibrin epitope γ
Indexed as
AnimalsAntibodies, MonoclonalEpitopesFibrinogenHumansInflammationMiceNeurodegenerative DiseasesRatsAntibodies, MonoclonalEpitopesFibrinogen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.