ArticleNature2018
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers.
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194citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
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Who cites it
194 citing papers in PubMed, 337 citations in OpenAlex.
- Cysteine-based molecular switches: a focus on KEAP1 and BACH1 in regulating the antioxidant response.Archives of toxicology · 2026Review
- Glycation proteomics identifies creatine kinase as a mediator of the effects of methylglyoxal on mitochondrial permeability transition.bioRxiv : the preprint server for biology · 2026Article
- ACT001 suppresses ox-LDL-mediated macrophage ferroptosis via activating the NRF2 pathway: AnExperimental and therapeutic medicine · 2026Article
- Glycolysis in bone remodeling: from energy supply to signaling regulation.Molecular biology reports · 2026Review
- PGK1 epigenetically silences STING via DNMT1 and its knockdown synergizes with STING agonists in pancreatic cancer.Acta pharmacologica Sinica · 2026Article
- Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers.Nature communications · 2026Article
- Methylglyoxal AttenuatesInternational journal of molecular sciences · 2026Article
- Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review).Oncology reports · 2026Review
- Nogo-B attenuates vascular calcification by activating NRF2-SLC7A11 to enhance antioxidant defense.Redox biology · 2026Article
- Covalent Modification of Keap1 by the Key Metabolic Cofactor Coenzyme A Under Oxidative and Metabolic Stress.Antioxidants (Basel, Switzerland) · 2026Article
- Non-Enzymatic MGO-Glycation of SRSF2 Drives RNA Mis-Splicing.Journal of the American Chemical Society · 2026Article
- GLUT6-facilitated noncanonical glucose metabolic rewiring enables resistance to targeted cancer therapy.Nature communications · 2026Article
- CILP Inhibits hyaline cartilage fibrosis and chondrocyte ferroptosis via keap1-Nrf2 axis in early osteoarthritis exercise therapy.Cellular and molecular life sciences : CMLS · 2026Article
- Discovery of metabolites produced by reactions between central carbon metabolites and cysteine that mark inflammatory macrophages.bioRxiv : the preprint server for biology · 2026Article
- Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study.European journal of nutrition · 2026Article
- Discovery of Glycation-Derived Cross-links at Arginine.Journal of the American Chemical Society · 2026Article
- LDHC4 promotes ovarian cancer progression through H4K12 lactylation to regulate PGK1 expression and modulate glycolysis.Journal of translational medicine · 2026Article
- EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.Nature communications · 2026Article
- Methylglyoxal-modification of NLRP3 interrupts NLRP3-NEK7 interaction diminishing inflammasome activation and neuroinflammation.Journal of neuroinflammation · 2026Article
- PRIME: an interpretable artificial intelligence model based on liquid biopsy improves prediction of progression risk in non-small cell lung cancer.Military Medical Research · 2026Article
134 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 2 countries.
Michael J BollongDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Gihoon LeeDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
John S CoukosDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Hwayoung YunDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Claudio ZambaldoDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Jae Won ChangDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Emily N ChinDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Insha AhmadDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
Arnab K ChatterjeeCalifornia Institute for Biomedical Research (Calibr), La Jolla, CA, USA.
Luke L LairsonDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. llairson@scripps.edu.
Peter G SchultzDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. schultz@scripps.edu.
Raymond E MoelleringDepartment of Chemistry, University of Chicago, Chicago, IL, USA. rmoellering@uchicago.edu.
Scripps Research Institute · USUniversity of Chicago · USCalifornia Institute for Biomedical Research · USPusan National University · KR
Funding
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MTargeting Transcription with Synthetic BiologicsDP2GM128199 · NIGMS · UNIVERSITY OF CHICAGO · PI MOELLERING, RAYMOND E · 2017 to 2017
$2.3MNicotinamide N-Methyltransferase (NNMT) as a master regulator of cancer stromaR01CA211916 · NCI · UNIVERSITY OF CHICAGO · PI LENGYEL, ERNST · 2017 to 2021
$1.9MMapping Protein Social Network Dynamics with Photoproximity Profiling PlatformsR01GM145852 · NIGMS · UNIVERSITY OF CHICAGO · PI MOELLERING, RAYMOND E · 2022 to 2025
$1.5MDistribution, regulation and function of a novel lysine PTM in metabolic diseaseR00CA175399 · NCI · UNIVERSITY OF CHICAGO · PI MOELLERING, RAYMOND E · 2015 to 2017
$712kDistribution, regulation and function of a novel lysine PTM in metabolic diseaseK99CA175399 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI MOELLERING, RAYMOND E · 2014 to 2014
$89kNCI NIH HHS K99 CA175399NCI NIH HHS R00 CA175399NCI NIH HHS R01 CA211916NIGMS NIH HHS DP2 GM128199NIGMS NIH HHS R01 GM145852NIGMS NIH HHS T32 GM007281
Abstract
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of enzymes
Indexed as
GlycolysisProtein Processing, Post-TranslationalSignal TransductionAnimalsAntioxidant Response ElementsArginineCell LineCysteineCytoprotectionHumansImidazolesKelch-Like ECH-Associated Protein 1MaleMiceMice, Inbred BALB CNF-E2-Related Factor 2ArginineCysteineImidazolesKEAP1 protein, humanKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNF-E2-Related Factor 2PGK1 protein, humanPhosphoglycerate KinasePyruvaldehyde
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.