ArticleNature neuroscience2018
The timing of action determines reward prediction signals in identified midbrain dopamine neurons.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed.
- Synapse-like specializations at dopamine release sites orchestrate efficient and precise neuromodulatory signaling.Science advances · 2026Article
- Distinct forms of dopamine transmission control locomotion and learning.bioRxiv : the preprint server for biology · 2026Article
- Cerebellar neural populations orchestrate dopamine reward signaling with single-trial precision.Nature communications · 2026Article
- Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong.bioRxiv : the preprint server for biology · 2026Article
- Prediction error correlates in the striosome-dopamine circuit emerge from information gain.Nature communications · 2026Article
- Demonstrating the ability of GABAergic cells in the zona incerta to modulate motivation.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporally Distinct Dopamine Domains in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Hybrid neural-cognitive models reveal how memory shapes human reward learning.Nature human behaviour · 2026Article
- Duration between rewards controls the rate of behavioral and dopaminergic learning.Nature neuroscience · 2026Article
- Rapid dopaminergic signatures in movement: Reach vigor reflects reward prediction error and learned expectation.Science advances · 2026Article
- Striatal Acetylcholine Dip-Rebound Is Induced by Direct-Pathway Neurons and Encode Action-Outcome Contingency.bioRxiv : the preprint server for biology · 2026Article
- Dopamine modulation of spike-timing-dependent plasticity for spatio-temporal spike pattern detection in single neurons.Frontiers in computational neuroscience · 2026Article
- Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum.Neuron · 2025Article
- Subsecond dopamine fluctuations do not specify the vigor of ongoing actions.Nature neuroscience · 2025Article
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning.Nature communications · 2025Article
- A hardwired neural circuit for temporal difference learning.bioRxiv : the preprint server for biology · 2025Article
- Sensitive dLight3 for imaging broad-spectrum dopamine events across brain regions.Research square · 2025Article
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60 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
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Abstract
Animals adapt their behavior in response to informative sensory cues using multiple brain circuits. The activity of midbrain dopaminergic neurons is thought to convey a critical teaching signal: reward-prediction error. Although reward-prediction error signals are thought to be essential to learning, little is known about the dynamic changes in the activity of midbrain dopaminergic neurons as animals learn about novel sensory cues and appetitive rewards. Here we describe a large dataset of cell-attached recordings of identified dopaminergic neurons as naive mice learned a novel cue-reward association. During learning midbrain dopaminergic neuron activity results from the summation of sensory cue-related and movement initiation-related response components. These components are both a function of reward expectation yet they are dissociable. Learning produces an increasingly precise coordination of action initiation following sensory cues that results in apparent reward-prediction error correlates. Our data thus provide new insights into the circuit mechanisms that underlie a critical computation in a highly conserved learning circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.