Evidence map›Paper›PMID 30323268›Full record

ArticleThe American journal of gastroenterology2018

Burden of Gastrointestinal Symptoms in the United States: Results of a Nationally Representative Survey of Over 71,000 Americans.

Christopher V Almario, Megana L Ballal, William D Chey, Carl Nordstrom, Dinesh Khanna, Brennan M R Spiegel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 6 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 6 syntheses or guidelines pooled it, 184 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. A systematic review and meta-analysis ofFrontiers in gastroenterology (Lausanne, Switzerland) · 2022
    Pooled it
  6. A non-invasive method for the diagnosis of upper GI diseases.Acta bio-medica : Atenei Parmensis · 2018
    Pooled it
  7. Trial
  8. Effect of PostbioticNutrients · 2024
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. The probioticGut microbes
    Trial
  14. Age and Sex Differences in Alcohol Withdrawal Syndrome.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Health Disparities in Irritable Bowel Syndrome.Gastroenterology & hepatology · 2025
    Article
  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Christopher V AlmarioDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA. Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Gastroenterology, Michigan Medicine, Ann Arbor, MI, USA. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, USA. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Megana L BallalDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA. Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Gastroenterology, Michigan Medicine, Ann Arbor, MI, USA. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, USA. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
William D CheyDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA. Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Gastroenterology, Michigan Medicine, Ann Arbor, MI, USA. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, USA. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Carl NordstromDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA. Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Gastroenterology, Michigan Medicine, Ann Arbor, MI, USA. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, USA. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Dinesh KhannaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA. Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Gastroenterology, Michigan Medicine, Ann Arbor, MI, USA. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, USA. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Brennan M R SpiegelDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Health Services Research, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Cedars-Sinai Center for Outcomes Research and Education (CS-CORE), Los Angeles, CA, USA. Division of Informatics, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Division of Gastroenterology, Michigan Medicine, Ann Arbor, MI, USA. Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Division of Rheumatology, Michigan Medicine, Ann Arbor, MI, USA. Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · USMichigan Medicine · USUCLA Health · USUniversity of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
NCATS NIH HHS UL1 TR001881
6 · The paper itself

Abstract

objectivesDigestive diseases account for >100 million ambulatory care visits annually in the U.S. Yet, comparatively less is known about the true burden of gastrointestinal (GI) symptoms in the general U.S. POPULATION: The aim of this study was to use data from the "National GI Survey"-a population-based audit of GI symptoms in >71,000 participants-to determine the prevalence and predictors of GI symptoms in community-dwelling Americans.

methodsWe conducted the National GI Survey using a mobile app called MyGiHealth, which employs a computer algorithm that systematically collects participants' GI symptoms. We recruited a nationally representative sample of Americans to complete the survey, which guided respondents through National Institutes of Health (NIH) GI Patient Reported Outcome Measurement Information System (PROMIS®) scales along with questions about relevant comorbidities and demographics. We measured the prevalence of GI symptoms in the past week and employed logistic regression to adjust for confounding.

resultsOverall, 71,812 individuals completed the survey, of which 61% reported having had ≥1 GI symptom in the past week. The most commonly reported symptoms were heartburn/reflux (30.9%), abdominal pain (24.8%), bloating (20.6%), diarrhea (20.2%), and constipation (19.7%). Less common symptoms were nausea/vomiting (9.5%), dysphagia (5.8%), and bowel incontinence (4.8%). Females, non-Hispanic whites, and individuals who were younger, highly educated, and had medical comorbidities were more likely to have symptoms (all adjusted p < 0.05).

conclusionsIn this large population-based study that combined digital health technology with NIH PROMIS questionnaires, we found that GI symptoms are highly prevalent, as nearly two thirds of surveyed Americans are burdened by these symptoms.

Indexed as

Patient Reported Outcome MeasuresAdultAgedCross-Sectional StudiesFemaleGastrointestinal DiseasesHealth SurveysHumansMaleMiddle AgedMobile ApplicationsPrevalenceRetrospective StudiesUnited StatesYoung Adult

Identifiers

PMID30323268
PMCPMC6453579
OpenAlexW2896621550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.