ArticleNature communications2018
Automated quantification of bioluminescence images.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Quantitative Preclinical Imaging as a Metrological Framework: Reproducibility, Validation, and Translational Maturity.Journal of imaging · 2026Review
- Tracking of Urine-Derived Stem Cells in Mice.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Urine-derived stem cells display homing, incorporation, and regeneration in human organoid and mouse models of acute kidney injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles.Chemical & biomedical imaging · 2025Review
- Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images.Journal of visualized experiments : JoVE · 2024Article
- Article
- Frameworks for transformational breakthroughs in RNA-based medicines.Nature reviews. Drug discovery · 2024Review
- In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of a commercial bioluminescence tomography-guided system for pre-clinical radiation research.Medical physics · 2023Article
- In vivo bioluminescence imaging of natural bacteria within deep tissues via ATP-binding cassette sugar transporter.Nature communications · 2023Article
- Development of Fluorescent Bacteria withInternational journal of molecular sciences · 2023Article
- Erratum: Bioluminescence tomography reconstruction in conjunction with an organ probability map as an anatomical reference: erratum.Biomedical optics express · 2023Article
- Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research.Biomedical optics express · 2022Article
- Tracking the fates of iron-labeled tumor cellsNanoscale advances · 2022Article
- Bioluminescence tomography reconstruction in conjunction with an organ probability map as an anatomical reference.Biomedical optics express · 2022Article
- Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research.International journal of radiation oncology, biology, physics · 2021Article
- Real-Time Noninvasive Bioluminescence, Ultrasound and Photoacoustic Imaging in NFκB-RE-Luc Transgenic Mice Reveal Glia Maturation Factor-Mediated Immediate and Sustained Spatio-Temporal Activation of NFκB Signaling Post-Traumatic Brain Injury in a Gender-Specific Manner.Cellular and molecular neurobiology · 2021Article
- Generation of Fluorescent Bacteria with the Genes Coding for Lumazine Protein and Riboflavin Biosynthesis.Sensors (Basel, Switzerland) · 2021Article
- Small animal PET: a review of what we have done and where we are going.Physics in medicine and biology · 2020Review
- Evaluating the Reproducibility of Mouse Anatomy under Rotation in a Custom Immobilization Device for Conformal FLASH Radiotherapy.Radiation research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We developed a computer-aided analysis tool for quantitatively determining bioluminescent reporter distributions inside small animals. The core innovations are a body-fitting animal shuttle and a statistical mouse atlas, both of which are spatially aligned and scaled according to the animal's weight, and hence provide data congruency across animals of varying size and pose. In conjunction with a multispectral bioluminescence tomography technique capitalizing on the spatial framework of the shuttle, the in vivo biodistribution of luminescent reporters can rapidly be calculated and, thus, enables operator-independent and computer-driven data analysis. We demonstrate its functionality by quantitatively monitoring a bacterial infection, where the bacterial organ burden was determined and validated with the established serial-plating method. In addition, the statistical mouse atlas was validated and compared to existing techniques providing an anatomical reference. The proposed data analysis tool promises to increase data throughput and data reproducibility and accelerate human disease modeling in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.