ArticleNature microbiology2018
Structural and functional insights into the regulation of the lysis-lysogeny decision in viral communities.
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026Review
- A diverse gut virome in natural populations of Drosophila melanogaster.Animal microbiome · 2026Article
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- Eco-evolutionary strategies drive viral diversification in nutrient-poor soils across elevation gradients.National science review · 2025Article
- Lysogenic control of Bacillus subtilis morphology and fitness by Spbetavirus phi3T.Communications biology · 2025Article
- The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.Viruses · 2025Review
- CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB.Virologica Sinica · 2025Article
- Structural and functional characterization of MrpR, the master repressor of the Bacillus subtilis prophage SPβ.Nucleic acids research · 2023Article
- Viral lysing can alleviate microbial nutrient limitations and accumulate recalcitrant dissolved organic matter components in soil.The ISME journal · 2023Article
- Current trends in management of bacterial pathogens infecting plants.Antonie van Leeuwenhoek · 2023Review
- The Structure and Function of Biomaterial Endolysin EFm1 fromMaterials (Basel, Switzerland) · 2022Article
- Insights into the mechanism of action of the arbitrium communication system in SPbeta phages.Nature communications · 2022Article
- Structural insights into the catalytic and inhibitory mechanisms of the flavin transferase FmnB inMedComm · 2022Article
- Bacteriophages and their potential for treatment of gastrointestinal diseases.Nature reviews. Gastroenterology & hepatology · 2022Review
- Chronic Release of Tailless Phage Particles from Lactococcus lactis.Applied and environmental microbiology · 2022Article
- Regulation of prophage induction and lysogenization by phage communication systems.Current biology : CB · 2021Article
- AimR Adopts Preexisting Dimer Conformations for Specific Target Recognition in Lysis-Lysogeny Decisions ofBiomolecules · 2021Article
- The impact of quorum sensing on the modulation of phage-host interactions.Journal of bacteriology · 2021Review
- Social Bacteriophages.Microorganisms · 2020Review
- Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Communication is vital for all organisms including microorganisms, which is clearly demonstrated by the bacterial quorum-sensing system. However, the molecular mechanisms underlying communication among viruses (phages) via the quorum-sensing-like 'arbitrium' system remain unclear. Viral or host densities are known to be related to an increased prevalence of lysogeny; however, how the switch from the lytic to the lysogenic pathway occurs is unknown. Thus, we sought to reveal mechanisms of communication among viruses and determine the lysogenic dynamics involved. Structural and functional analyses of the phage-derived SAIRGA and GMPRGA peptides and their corresponding receptors, phAimR and spAimR, indicated that SAIRGA directs the lysis-lysogeny decision of phi3T by modulating conformational changes in phAimR, whereas GMPRGA regulates the lysis-lysogeny pathway by stabilizing spAimR in the dimeric state. Although temperate viruses are thought to share a similar lytic-lysogenic cycle switch model, our study suggests the existence of alternative strain-specific mechanisms that regulate the lysis-lysogeny decision. Collectively, these findings provide insights into the molecular mechanisms underlying communication among viruses, offering theoretical applications for the treatment of infectious viral diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.