ArticleScientific reports2018
Genome-wide identification of geographical segregated genetic markers in Salmonella enterica serovar Typhimurium variant 4,[5],12:i:.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Using GWAS and Machine Learning to Identify and Predict Genetic Variants Associated with Foodborne Bacteria Phenotypic Traits.Methods in molecular biology (Clifton, N.J.) · 2025Review
- High diversity ofFrontiers in microbiology · 2023Article
- The genomic and epidemiological virulence patterns of Salmonella enterica serovars in the United States.PloS one · 2023Article
- Tell me if you prefer bovine or poultry sectors and I'll tell you who you are: Characterization ofFrontiers in microbiology · 2023Article
- Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.Italian journal of food safety · 2022Article
- Evaluation of Antimicrobial Resistance inMicroorganisms · 2022Article
- Relationship and distribution of Salmonella enterica serovar I 4,[5],12:i:- strain sequences in the NCBI Pathogen Detection database.BMC genomics · 2022Article
- Genomic Characterization of Endemic and Ecdemic Non-typhoidalFrontiers in microbiology · 2021Article
- Population structure, case clusters, and genetic lesions associated with Canadian Salmonella 4,[5],12:i:- isolates.PloS one · 2021Article
- The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant MonophasicFrontiers in microbiology · 2021Article
- Monitoring the Microevolution ofFrontiers in microbiology · 2021Article
- Whole-genome epidemiology links phage-mediated acquisition of a virulence gene to the clonal expansion of a pandemicMicrobial genomics · 2020Article
- AB_SA: Accessory genes-Based Source Attribution - tracing the source ofMicrobial genomics · 2020Article
- Network Approach to Source Attribution ofFrontiers in microbiology · 2020Article
- Whole genome sequencing and metagenomics for outbreak investigation, source attribution and risk assessment of food-borne microorganisms.EFSA journal. European Food Safety Authority · 2019Article
- Genetic and metabolic signatures of Salmonella enterica subsp. enterica associated with animal sources at the pangenomic scale.BMC genomics · 2019Article
- Raw meat-based diets for companion animals: a potential source of transmission of pathogenic and antimicrobial-resistant Enterobacteriaceae.Royal Society open science · 2019Article
- Geography Shapes the Population Genomics of Salmonella enterica Dublin.Genome biology and evolution · 2019Article
- Multidrug-ResistantInternational journal of genomics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica ser. Typhimurium monophasic variant 4,[5],12:i:- has been associated with food-borne epidemics worldwide and swine appeared to be the main reservoir in most of the countries of isolation. However, the monomorphic nature of this serovar has, so far, hindered identification of the source due to expansion of clonal lineages in multiple hosts and food producing systems. Since geographically structured genetic signals can shape bacterial populations, identification of biogeographical markers in S. 1,4,[5],12:i:- genomes can contribute to improving source attribution. In this study, the phylogeographical structure of 148 geographically and temporally related Italian S. 1,4,[5],12:i:- has been investigated. The Italian isolates belong to a large population of clonal S. Typhimurium/1,4,[5],12:i:- isolates collected worldwide in two decades showing up to 2.5% of allele differences. Phylogenetic reconstruction revealed that isolates from the same geographical origin form highly supported monophyletic groups, suggesting discrete geographical segregation. These monophyletic groups are characterized by the gene content of a large sopE-containing prophage. Within this prophage, genome-wide comparison identified several genes overrepresented in strains of Italian origin. This suggests that certain lineages may be characterized by the acquisition of specific accessory genetic markers useful for improving identification of the source in ongoing epidemics.
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