Evidence map›Paper›PMID 30323063›Full record

ArticleThe Journal of biological chemistry2018

MicroRNA-664-5p promotes myoblast proliferation and inhibits myoblast differentiation by targeting serum response factor and

Rui Cai, Naren Qimuge, Meilin Ma, Yingqian Wang, Guorong Tang, Que Zhang, Yunmei Sun, Xiaochang Chen, Taiyong Yu, Wuzi Dong and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rui CaiFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.ORCID 0000-0001-6163-8823
Naren QimugeFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Meilin MaFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Yingqian WangFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Guorong TangFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Que ZhangFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Yunmei SunFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.ORCID 0000-0003-2883-2012
Xiaochang ChenFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.ORCID 0000-0002-5706-2080
Taiyong YuFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Wuzi DongFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Gongshe YangFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China.
Weijun PangFrom the Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling Shaanxi 712100, China pwj1226@nwsuaf.edu.cn.ORCID 0000-0003-1740-6536
North West Agriculture and Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression at the post-transcriptional level and are involved in the regulation of the formation, maintenance, and function of skeletal muscle. Using miRNA sequencing and bioinformatics analysis, we previously found that the miRNA miR-664-5p is significantly differentially expressed in longissimus dorsi muscles of Rongchang pigs. However, the molecular mechanism by which miR-664-5p regulates myogenesis remains unclear. In this study, using flow cytometry, 5-ethynyl-2'-deoxyuridine staining, and cell count and immunofluorescent assays, we found that cell-transfected miR-664-5p mimics greatly promoted proliferation of C2C12 mouse myoblasts by increasing the proportion of cells in the S- and G

Indexed as

AnimalsCell DifferentiationCell ProliferationDown-RegulationHEK293 CellsHumansMiceMicroRNAsMuscle DevelopmentMyoblastsRNA, MessengerSerum Response FactorWnt1 ProteinWnt Signaling PathwayMicroRNAsMIRN664 microRNA, mouseRNA, MessengerSerum Response FactorWnt1 ProteinWnt1 protein, mousecell differentiationcell proliferationmicroRNA (miRNA)musclemyogenesispost-transcriptional regulationWnt pathway

Identifiers

PMID30323063
PMCPMC6302170
OpenAlexW2896039704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.