Evidence map›Paper›PMID 30323045›Full record

ArticleAntimicrobial agents and chemotherapy2019

Acquisition of Extended-Spectrum β-Lactamase GES-6 Leading to Resistance to Ceftolozane-Tazobactam Combination in

Laurent Poirel, José-Manuel Ortiz De La Rosa, Nicolas Kieffer, Véronique Dubois, Aurélie Jayol, Patrice Nordmann

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. L2 β-lactamase contributes to ceftolozane-tazobactam resistance inAntimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. A novel mechanism of ceftolozane-tazobactam resistance inbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Multidrug-resistantVirulence · 2025
    Review
  7. Review
  8. Novel resistance ICEs carrying theAntimicrobial agents and chemotherapy · 2024
    Article
  9. Article
  10. NDM-35-Producing ST167Antimicrobial agents and chemotherapy · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.Antimicrobial agents and chemotherapy · 2019
    Article
  19. A 2.5-years within-patient evolution of aAntimicrobial agents and chemotherapy · 2019
    Article
  20. Extensively Drug-ResistantOpen forum infectious diseases · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Laurent PoirelEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland laurent.poirel@unifr.ch.
José-Manuel Ortiz De La RosaEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Nicolas KiefferEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Véronique DuboisLaboratory of Bacteriology, Bordeaux University Hospital, Bordeaux, France.
Aurélie JayolEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Patrice NordmannEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
University of Fribourg · CHCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A clinical

Indexed as

Amino Acid SubstitutionAnti-Bacterial AgentsAzabicyclo Compoundsbeta-Lactamasesbeta-Lactam ResistanceCarbapenemsCeftazidimeCephalosporinsDrug CombinationsGene ExpressionHumansMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsTazobactamAnti-Bacterial Agentsavibactamavibactam, ceftazidime drug combinationAzabicyclo Compoundsbeta-LactamasesCarbapenemsCeftazidimeceftolozaneceftolozane, tazobactam drug combinationCephalosporinsDrug CombinationsTazobactamceftolozane-tazobactamESBLGES-6Pseudomonas aeruginosa

Identifiers

PMID30323045
PMCPMC6325188
OpenAlexW2896307216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.