Evidence map›Paper›PMID 30323042›Full record

ArticleAntimicrobial agents and chemotherapy2019

Activation of 2,4-Diaminoquinazoline in

Eduard Melief, Shilah A Bonnett, Edison S Zuniga, Tanya Parish

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Transcriptional Response ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Eduard MeliefTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Shilah A BonnettTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Edison S ZunigaTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Tanya ParishTB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA tanya.parish@idri.org.
Infectious Disease Research Institute · US

Funding

Chemical probes of vulnerable pathways in antibiotic-resistant pathogensR01AI099188 · NIAID · ACCESS TO ADVANCED HEALTH INSTITUTE · PI PARISH, TANYA · 2012 to 2016
$3.7M
NIAID NIH HHS R01 AI099188
6 · The paper itself

Abstract

The diaminoquinazoline series has good potency against

Indexed as

Antitubercular AgentsDioxygenasesHumansMixed Function OxygenasesMycobacterium tuberculosisQuinazolinesStructure-Activity RelationshipTranscription Factors2,4-diaminoquinazolineAntitubercular AgentsDioxygenasesMixed Function OxygenasesQuinazolinesRv3291C protein, Mycobacterium tuberculosisTranscription FactorsantituberculardiaminoquinazolinedioxygenasesmonooxygenasesMycobacterium tuberculosisprodrug

Identifiers

PMID30323042
PMCPMC6325208
OpenAlexW2953355383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.