ArticleAntimicrobial agents and chemotherapy2019
Daptomycin Pore Formation and Stoichiometry Depend on Membrane Potential of Target Membrane.
Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Olikomycin A Disrupts Gram-Positive Bacterial Membranes Through Calcium-Dependent Binding to Phosphatidylglycerol.Archiv der Pharmazie · 2026Article
- The postantibiotic effect-like effect of photothermal agents: evidence from IR780 nanoparticles and indocyanine green.Frontiers in pharmacology · 2026Article
- The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action.Nature communications · 2025Article
- Biocompatible Guanidine-Functionalized Compounds with Biofilm and Membrane Disruptive Activity Against MRSA.ACS infectious diseases · 2025Article
- State of the Art of Cyclic Lipopeptide-Membrane Interactions: Pore Formation and Bilayer Permeability.Pharmaceutics · 2025Review
- Studies on the antibacterial activity of the antimicrobial peptide Mastoparan X against methicillin-resistantFrontiers in cellular and infection microbiology · 2025Article
- Overexpression of diglucosyldiacylglycerol synthase leads to daptomycin resistance inJournal of bacteriology · 2024Article
- Article
- Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action.Antibiotics (Basel, Switzerland) · 2023Review
- The Mechanism of Antimicrobial Activity of Conjugated Bile Acids against Lactic Acid Bacilli.Microorganisms · 2023Article
- LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.Journal of medicinal chemistry · 2022Article
- Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins.Scientific reports · 2021Article
- The Antibiotic Peptide Daptomycin Functions by Reorganizing the Membrane.The Journal of membrane biology · 2021Review
- Brevibacillin 2V Exerts Its Bactericidal ActivityFrontiers in microbiology · 2021Article
- High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action.Nature communications · 2020Article
- Model lipid systems and their use to evaluate the phase state of biomembranes, their mechanical properties and the effect of non-conventional antibiotics: the case of daptomycin.European biophysics journal : EBJ · 2020Article
- Physicochemical Characterization of Daptomycin Interaction with Negatively Charged Lipid Membranes.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Development and Challenges of Antimicrobial Peptides for Therapeutic Applications.Antibiotics (Basel, Switzerland) · 2020Review
- More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin.Antibiotics (Basel, Switzerland) · 2020Review
- Native Mass Spectrometry of Antimicrobial Peptides in Lipid Nanodiscs Elucidates Complex Assembly.Analytical chemistry · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Daptomycin is a calcium-dependent lipodepsipeptide antibiotic clinically used to treat serious infections caused by Gram-positive pathogens. Its precise mode of action is somewhat controversial; the biggest issue is daptomycin pore formation, which we directly investigated here. We first performed a screening experiment using propidium iodide (PI) entry to
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.