Evidence map›Paper›PMID 30322964›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis.

Igor Maricic, Idania Marrero, Akiko Eguchi, Ryota Nakamura, Casey D Johnson, Suryasarathi Dasgupta, Carolyn D Hernandez, Phirum Sam Nguyen, Austin D Swafford, Rob Knight and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 91 citations in OpenAlex.

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  20. Frontiers in immunology · 2023
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Igor MaricicDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.
Idania MarreroDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-5793-706X
Akiko EguchiDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Ryota NakamuraDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Casey D JohnsonDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Suryasarathi DasguptaDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.
Carolyn D HernandezDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.
Phirum Sam NguyenDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.
Austin D SwaffordCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-5655-8300
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Ariel E FeldsteinDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093.
Rohit LoombaDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-4845-9991
Vipin KumarDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA 92093; vckumar@ucsd.edu.
University of California San Diego · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Sulfatide-reactive type II NKT cells: repertoire and functionR01CA100660 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMAR, VIPIN · 2004 to 2014
$3.5M
Interplay Among NKT Cell Subsets in Alcoholic Liver DiseaseR01AA020864 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMAR, VIPIN · 2012 to 2016
$1.8M
NCI NIH HHS R01 CA100660NIAAA NIH HHS R01 AA020864NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Innate immune mechanisms play an important role in inflammatory chronic liver diseases. In this study, we investigated the role of type I or invariant NKT (iNKT) cell subsets in the progression of nonalcoholic steatohepatitis (NASH). We used α-galactosylceramide/CD1d tetramers and clonotypic mAb together with intracytoplasmic cytokine staining to analyze iNKT cells in choline-deficient l-amino acid-defined (CDAA)-induced murine NASH model and in human PBMCs, respectively. Cytokine secretion of hepatic iNKT cells in CDAA-fed C57BL/6 mice altered from predominantly IL-17

Indexed as

AnimalsDisease ProgressionHumansLymphocyte ActivationMiceMice, Inbred C57BLNatural Killer T-CellsNon-alcoholic Fatty Liver DiseaseT-Lymphocyte Subsets

Identifiers

PMID30322964
PMCPMC6219905
OpenAlexW2897407482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.